BDBM26740 N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carboxamide::PF-750
SMILES: O=C(Nc1ccccc1)N1CCC(Cc2cnc3ccccc3c2)CC1
InChI Key: InChIKey=BIODYGOZWZNCAG-UHFFFAOYSA-N
Data: 10 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM26740 (N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ catholique de Louvain Curated by ChEMBL | Assay Description Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting | J Med Chem 54: 6812-23 (2011) Article DOI: 10.1021/jm200723m BindingDB Entry DOI: 10.7270/Q2FB542J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM26740 (N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MCPHS University Curated by ChEMBL | Assay Description Irreversible inhibition of human recombinant FAAH using N-arachidonyl-7-amino-4-methylcoumarin as substrate preincubated for 20 mins before substrate... | Bioorg Med Chem 21: 5188-97 (2013) Article DOI: 10.1016/j.bmc.2013.06.034 BindingDB Entry DOI: 10.7270/Q2DJ5H2V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM26740 (N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 595 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o... | Biochemistry 46: 13019-30 (2007) Article DOI: 10.1021/bi701378g BindingDB Entry DOI: 10.7270/Q2VT1QCN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM26740 (N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 248 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o... | Biochemistry 46: 13019-30 (2007) Article DOI: 10.1021/bi701378g BindingDB Entry DOI: 10.7270/Q2VT1QCN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM26740 (N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal -His6 tagged FAAH (32 to 579 residues) expressed in Escherichia coli BL21 preincubated for 60 mins followe... | J Med Chem 60: 4-46 (2017) Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM26740 (N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 16.2 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o... | Biochemistry 46: 13019-30 (2007) Article DOI: 10.1021/bi701378g BindingDB Entry DOI: 10.7270/Q2VT1QCN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM26740 (N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 16.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Vernalis (R&D) Ltd Curated by ChEMBL | Assay Description Inhibition of FAAH | Bioorg Med Chem Lett 19: 4241-4 (2009) Article DOI: 10.1016/j.bmcl.2009.05.097 BindingDB Entry DOI: 10.7270/Q28S4PZC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM26740 (N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Ltd Curated by ChEMBL | Assay Description Inhibition of FAAH (unknown origin) | Bioorg Med Chem 21: 28-41 (2012) Article DOI: 10.1016/j.bmc.2012.11.006 BindingDB Entry DOI: 10.7270/Q2FN17H6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM26740 (N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 595 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal -His6 tagged FAAH (32 to 579 residues) expressed in Escherichia coli BL21-AI preincubated for 5 mins follo... | J Med Chem 60: 4-46 (2017) Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM26740 (N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 51.9 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o... | Biochemistry 46: 13019-30 (2007) Article DOI: 10.1021/bi701378g BindingDB Entry DOI: 10.7270/Q2VT1QCN | |||||||||||
More data for this Ligand-Target Pair |