BDBM268828 US9718825, Example 233

SMILES: COc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(OCC2(CN)COC2)c2cn[nH]c2n1

InChI Key: InChIKey=IKRDEPHHZIRHJN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 268828   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM268828 (US9718825, Example 233) Show SMILES COc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(OCC2(CN)COC2)c2cn[nH]c2n1 Show InChI InChI=1S/C23H23ClN6O5S/c1-33-16-6-7-18(24)19(8-16)36(31,32)30-15-4-2-14(3-5-15)20-27-21-17(9-26-29-21)22(28-20)35-13-23(10-25)11-34-12-23/h2-9,30H,10-13,25H2,1H3,(H,26,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.850	n/a	n/a	n/a	n/a	7.4	n/a
SANOFI US Patent					Assay Description The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...				US Patent US9718825 (2017) BindingDB Entry DOI: 10.7270/Q2VM4F82
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