BDBM26907 8-[bis(2-chlorophenyl)methyl]-1-phenyl-3-[2-(propan-2-ylamino)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one::spiropiperidine analogue, 28

SMILES: CC(C)NCCN1CN(c2ccccc2)C2(CCN(CC2)C(c2ccccc2Cl)c2ccccc2Cl)C1=O

InChI Key: InChIKey=XPASHGDCAWWZDI-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 26907   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM26907 (8-[bis(2-chlorophenyl)methyl]-1-phenyl-3-[2-(propa...) Show SMILES CC(C)NCCN1CN(c2ccccc2)C2(CCN(CC2)C(c2ccccc2Cl)c2ccccc2Cl)C1=O Show InChI InChI=1S/C31H36Cl2N4O/c1-23(2)34-18-21-36-22-37(24-10-4-3-5-11-24)31(30(36)38)16-19-35(20-17-31)29(25-12-6-8-14-27(25)32)26-13-7-9-15-28(26)33/h3-15,23,29,34H,16-22H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.55	-11.6	n/a	n/a	n/a	n/a	n/a	7.4	22
Schering-Plough Research Institute					Assay Description IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...				Bioorg Med Chem Lett 19: 1164-7 (2009) Article DOI: 10.1016/j.bmcl.2008.12.092 BindingDB Entry DOI: 10.7270/Q2TT4P95
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM26907 (8-[bis(2-chlorophenyl)methyl]-1-phenyl-3-[2-(propa...) Show SMILES CC(C)NCCN1CN(c2ccccc2)C2(CCN(CC2)C(c2ccccc2Cl)c2ccccc2Cl)C1=O Show InChI InChI=1S/C31H36Cl2N4O/c1-23(2)34-18-21-36-22-37(24-10-4-3-5-11-24)31(30(36)38)16-19-35(20-17-31)29(25-12-6-8-14-27(25)32)26-13-7-9-15-28(26)33/h3-15,23,29,34H,16-22H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	469	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...				Bioorg Med Chem Lett 19: 1164-7 (2009) Article DOI: 10.1016/j.bmcl.2008.12.092 BindingDB Entry DOI: 10.7270/Q2TT4P95
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM26907 (8-[bis(2-chlorophenyl)methyl]-1-phenyl-3-[2-(propa...) Show SMILES CC(C)NCCN1CN(c2ccccc2)C2(CCN(CC2)C(c2ccccc2Cl)c2ccccc2Cl)C1=O Show InChI InChI=1S/C31H36Cl2N4O/c1-23(2)34-18-21-36-22-37(24-10-4-3-5-11-24)31(30(36)38)16-19-35(20-17-31)29(25-12-6-8-14-27(25)32)26-13-7-9-15-28(26)33/h3-15,23,29,34H,16-22H2,1-2H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	745	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...				Bioorg Med Chem Lett 19: 1164-7 (2009) Article DOI: 10.1016/j.bmcl.2008.12.092 BindingDB Entry DOI: 10.7270/Q2TT4P95
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM26907 (8-[bis(2-chlorophenyl)methyl]-1-phenyl-3-[2-(propa...) Show SMILES CC(C)NCCN1CN(c2ccccc2)C2(CCN(CC2)C(c2ccccc2Cl)c2ccccc2Cl)C1=O Show InChI InChI=1S/C31H36Cl2N4O/c1-23(2)34-18-21-36-22-37(24-10-4-3-5-11-24)31(30(36)38)16-19-35(20-17-31)29(25-12-6-8-14-27(25)32)26-13-7-9-15-28(26)33/h3-15,23,29,34H,16-22H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	955	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...				Bioorg Med Chem Lett 19: 1164-7 (2009) Article DOI: 10.1016/j.bmcl.2008.12.092 BindingDB Entry DOI: 10.7270/Q2TT4P95
					More data for this Ligand-Target Pair