BDBM26909 8-[bis(2-chlorophenyl)methyl]-3-[2-(cyclohexylamino)ethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::spiropiperidine analogue, 30

SMILES: Clc1ccccc1C(N1CCC2(CC1)N(CN(CCNC1CCCCC1)C2=O)c1ccccc1)c1ccccc1Cl

InChI Key: InChIKey=PZRQTLDSILZECV-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 26909   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM26909 (8-[bis(2-chlorophenyl)methyl]-3-[2-(cyclohexylamin...) Show SMILES Clc1ccccc1C(N1CCC2(CC1)N(CN(CCNC1CCCCC1)C2=O)c1ccccc1)c1ccccc1Cl Show InChI InChI=1S/C34H40Cl2N4O/c35-30-17-9-7-15-28(30)32(29-16-8-10-18-31(29)36)38-22-19-34(20-23-38)33(41)39(24-21-37-26-11-3-1-4-12-26)25-40(34)27-13-5-2-6-14-27/h2,5-10,13-18,26,32,37H,1,3-4,11-12,19-25H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	5	-11.2	n/a	n/a	n/a	n/a	n/a	7.4	22
Schering-Plough Research Institute					Assay Description IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...				Bioorg Med Chem Lett 19: 1164-7 (2009) Article DOI: 10.1016/j.bmcl.2008.12.092 BindingDB Entry DOI: 10.7270/Q2TT4P95
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM26909 (8-[bis(2-chlorophenyl)methyl]-3-[2-(cyclohexylamin...) Show SMILES Clc1ccccc1C(N1CCC2(CC1)N(CN(CCNC1CCCCC1)C2=O)c1ccccc1)c1ccccc1Cl Show InChI InChI=1S/C34H40Cl2N4O/c35-30-17-9-7-15-28(30)32(29-16-8-10-18-31(29)36)38-22-19-34(20-23-38)33(41)39(24-21-37-26-11-3-1-4-12-26)25-40(34)27-13-5-2-6-14-27/h2,5-10,13-18,26,32,37H,1,3-4,11-12,19-25H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	224	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...				Bioorg Med Chem Lett 19: 1164-7 (2009) Article DOI: 10.1016/j.bmcl.2008.12.092 BindingDB Entry DOI: 10.7270/Q2TT4P95
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM26909 (8-[bis(2-chlorophenyl)methyl]-3-[2-(cyclohexylamin...) Show SMILES Clc1ccccc1C(N1CCC2(CC1)N(CN(CCNC1CCCCC1)C2=O)c1ccccc1)c1ccccc1Cl Show InChI InChI=1S/C34H40Cl2N4O/c35-30-17-9-7-15-28(30)32(29-16-8-10-18-31(29)36)38-22-19-34(20-23-38)33(41)39(24-21-37-26-11-3-1-4-12-26)25-40(34)27-13-5-2-6-14-27/h2,5-10,13-18,26,32,37H,1,3-4,11-12,19-25H2	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...				Bioorg Med Chem Lett 19: 1164-7 (2009) Article DOI: 10.1016/j.bmcl.2008.12.092 BindingDB Entry DOI: 10.7270/Q2TT4P95
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM26909 (8-[bis(2-chlorophenyl)methyl]-3-[2-(cyclohexylamin...) Show SMILES Clc1ccccc1C(N1CCC2(CC1)N(CN(CCNC1CCCCC1)C2=O)c1ccccc1)c1ccccc1Cl Show InChI InChI=1S/C34H40Cl2N4O/c35-30-17-9-7-15-28(30)32(29-16-8-10-18-31(29)36)38-22-19-34(20-23-38)33(41)39(24-21-37-26-11-3-1-4-12-26)25-40(34)27-13-5-2-6-14-27/h2,5-10,13-18,26,32,37H,1,3-4,11-12,19-25H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	759	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...				Bioorg Med Chem Lett 19: 1164-7 (2009) Article DOI: 10.1016/j.bmcl.2008.12.092 BindingDB Entry DOI: 10.7270/Q2TT4P95
					More data for this Ligand-Target Pair