BDBM269140 US9718825, Example 586

SMILES: Cc1n[nH]c2cc(nc(OC3CCN(CC3)C3CC3)c12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2C#N)cc1

InChI Key: InChIKey=JELPOQZRSIROOT-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 269140   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM269140 (US9718825, Example 586) Show SMILES Cc1n[nH]c2cc(nc(OC3CCN(CC3)C3CC3)c12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2C#N)cc1 Show InChI InChI=1S/C29H30N6O3S/c1-18-3-4-21(17-30)27(15-18)39(36,37)34-22-7-5-20(6-8-22)25-16-26-28(19(2)32-33-26)29(31-25)38-24-11-13-35(14-12-24)23-9-10-23/h3-8,15-16,23-24,34H,9-14H2,1-2H3,(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.4	n/a
SANOFI US Patent					Assay Description The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...				US Patent US9718825 (2017) BindingDB Entry DOI: 10.7270/Q2VM4F82
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