BDBM26917 8-[bis(2-chlorophenyl)methyl]-1-phenyl-3-[3-(pyrrolidin-1-yl)propyl]-1,3,8-triazaspiro[4.5]decan-4-one::spiropiperidine analogue, 38

SMILES: Clc1ccccc1C(N1CCC2(CC1)N(CN(CCCN1CCCC1)C2=O)c1ccccc1)c1ccccc1Cl

InChI Key: InChIKey=ZQXJEKRACRYDRN-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 26917   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM26917 (8-[bis(2-chlorophenyl)methyl]-1-phenyl-3-[3-(pyrro...) Show SMILES Clc1ccccc1C(N1CCC2(CC1)N(CN(CCCN1CCCC1)C2=O)c1ccccc1)c1ccccc1Cl Show InChI InChI=1S/C33H38Cl2N4O/c34-29-15-6-4-13-27(29)31(28-14-5-7-16-30(28)35)37-23-17-33(18-24-37)32(40)38(22-10-21-36-19-8-9-20-36)25-39(33)26-11-2-1-3-12-26/h1-7,11-16,31H,8-10,17-25H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	3.20	-11.5	n/a	n/a	n/a	n/a	n/a	7.4	22
Schering-Plough Research Institute					Assay Description IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...				Bioorg Med Chem Lett 19: 1164-7 (2009) Article DOI: 10.1016/j.bmcl.2008.12.092 BindingDB Entry DOI: 10.7270/Q2TT4P95
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM26917 (8-[bis(2-chlorophenyl)methyl]-1-phenyl-3-[3-(pyrro...) Show SMILES Clc1ccccc1C(N1CCC2(CC1)N(CN(CCCN1CCCC1)C2=O)c1ccccc1)c1ccccc1Cl Show InChI InChI=1S/C33H38Cl2N4O/c34-29-15-6-4-13-27(29)31(28-14-5-7-16-30(28)35)37-23-17-33(18-24-37)32(40)38(22-10-21-36-19-8-9-20-36)25-39(33)26-11-2-1-3-12-26/h1-7,11-16,31H,8-10,17-25H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	64	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...				Bioorg Med Chem Lett 19: 1164-7 (2009) Article DOI: 10.1016/j.bmcl.2008.12.092 BindingDB Entry DOI: 10.7270/Q2TT4P95
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM26917 (8-[bis(2-chlorophenyl)methyl]-1-phenyl-3-[3-(pyrro...) Show SMILES Clc1ccccc1C(N1CCC2(CC1)N(CN(CCCN1CCCC1)C2=O)c1ccccc1)c1ccccc1Cl Show InChI InChI=1S/C33H38Cl2N4O/c34-29-15-6-4-13-27(29)31(28-14-5-7-16-30(28)35)37-23-17-33(18-24-37)32(40)38(22-10-21-36-19-8-9-20-36)25-39(33)26-11-2-1-3-12-26/h1-7,11-16,31H,8-10,17-25H2	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	436	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...				Bioorg Med Chem Lett 19: 1164-7 (2009) Article DOI: 10.1016/j.bmcl.2008.12.092 BindingDB Entry DOI: 10.7270/Q2TT4P95
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM26917 (8-[bis(2-chlorophenyl)methyl]-1-phenyl-3-[3-(pyrro...) Show SMILES Clc1ccccc1C(N1CCC2(CC1)N(CN(CCCN1CCCC1)C2=O)c1ccccc1)c1ccccc1Cl Show InChI InChI=1S/C33H38Cl2N4O/c34-29-15-6-4-13-27(29)31(28-14-5-7-16-30(28)35)37-23-17-33(18-24-37)32(40)38(22-10-21-36-19-8-9-20-36)25-39(33)26-11-2-1-3-12-26/h1-7,11-16,31H,8-10,17-25H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.38E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...				Bioorg Med Chem Lett 19: 1164-7 (2009) Article DOI: 10.1016/j.bmcl.2008.12.092 BindingDB Entry DOI: 10.7270/Q2TT4P95
					More data for this Ligand-Target Pair