BDBM2692 3-(1H-indol-3-yl)-4-{1-[(1-methylpiperidin-3-yl)methyl]-1H-indol-3-yl}-2,5-dihydro-1H-pyrrole-2,5-dione::Bisindolyl deriv. 20

SMILES: CN1CCCC(Cn2cc(C3=C(C(=O)NC3=O)c3c[nH]c4ccccc34)c3ccccc23)C1

InChI Key: InChIKey=HBSZWHXBVARXJV-UHFFFAOYSA-N

Data: 3 IC50

PDB links: 9 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 2692   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-Dependent Protein Kinase (PKA) (Bos taurus (bovine))	BDBM2692 (3-(1H-indol-3-yl)-4-{1-[(1-methylpiperidin-3-yl)me...) Show SMILES CN1CCCC(Cn2cc(C3=C(C(=O)NC3=O)c3c[nH]c4ccccc34)c3ccccc23)C1 |t:10| Show InChI InChI=1S/C27H26N4O2/c1-30-12-6-7-17(14-30)15-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-13-28-22-10-4-2-8-18(20)22/h2-5,8-11,13,16-17,28H,6-7,12,14-15H2,1H3,(H,29,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Laboratoires Glaxo					Assay Description The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi...				J Biol Chem 266: 15771-81 (1991) BindingDB Entry DOI: 10.7270/Q2FF3QJ4
					More data for this Ligand-Target Pair
Phosphorylase Kinase (Oryctolagus cuniculus (rabbit))	BDBM2692 (3-(1H-indol-3-yl)-4-{1-[(1-methylpiperidin-3-yl)me...) Show SMILES CN1CCCC(Cn2cc(C3=C(C(=O)NC3=O)c3c[nH]c4ccccc34)c3ccccc23)C1 |t:10| Show InChI InChI=1S/C27H26N4O2/c1-30-12-6-7-17(14-30)15-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-13-28-22-10-4-2-8-18(20)22/h2-5,8-11,13,16-17,28H,6-7,12,14-15H2,1H3,(H,29,32,33)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratoires Glaxo					Assay Description The activity of PK is measured by its ability to transfer from [gamma-32P]ATP to phosphorylase b.				J Biol Chem 266: 15771-81 (1991) BindingDB Entry DOI: 10.7270/Q2FF3QJ4
					More data for this Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA) (Rattus norvegicus (rat))	BDBM2692 (3-(1H-indol-3-yl)-4-{1-[(1-methylpiperidin-3-yl)me...) Show SMILES CN1CCCC(Cn2cc(C3=C(C(=O)NC3=O)c3c[nH]c4ccccc34)c3ccccc23)C1 |t:10| Show InChI InChI=1S/C27H26N4O2/c1-30-12-6-7-17(14-30)15-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-13-28-22-10-4-2-8-18(20)22/h2-5,8-11,13,16-17,28H,6-7,12,14-15H2,1H3,(H,29,32,33)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratoires Glaxo					Assay Description The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.				J Biol Chem 266: 15771-81 (1991) BindingDB Entry DOI: 10.7270/Q2FF3QJ4
					More data for this Ligand-Target Pair