BDBM269435 (E)-3-(4-((2-(3-fluoro- 2- (trifluoromethyl) phenyl)-6- hydroxybenzo[b] thiophen-3- yl)oxy)phenyl)acrylic acid::US10058534, 90

SMILES: OC(=O)\C=C\c1ccc(Oc2c(sc3cc(O)ccc23)-c2cccc(F)c2C(F)(F)F)cc1

InChI Key: InChIKey=GCMDOOFJJQKWQF-IZZDOVSWSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 269435   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Estrogen receptor (Homo sapiens (Human))	BDBM269435 ((E)-3-(4-((2-(3-fluoro- 2- (trifluoromethyl) pheny...) Show SMILES OC(=O)\C=C\c1ccc(Oc2c(sc3cc(O)ccc23)-c2cccc(F)c2C(F)(F)F)cc1 Show InChI InChI=1S/C24H14F4O4S/c25-18-3-1-2-17(21(18)24(26,27)28)23-22(16-10-7-14(29)12-19(16)33-23)32-15-8-4-13(5-9-15)6-11-20(30)31/h1-12,29H,(H,30,31)/b11-6+	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.4	25
Novartis AG US Patent					Assay Description Plate MCF7 cells at 0.3 million cells/mL (100 l/well) in black, clear-bottom 96-well plates (Greiner, catalog number 655090) in DMEM/F12 media (Gibco...				US Patent US10058534 (2018) BindingDB Entry DOI: 10.7270/Q2M32XSG
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM269435 ((E)-3-(4-((2-(3-fluoro- 2- (trifluoromethyl) pheny...) Show SMILES OC(=O)\C=C\c1ccc(Oc2c(sc3cc(O)ccc23)-c2cccc(F)c2C(F)(F)F)cc1 Show InChI InChI=1S/C24H14F4O4S/c25-18-3-1-2-17(21(18)24(26,27)28)23-22(16-10-7-14(29)12-19(16)33-23)32-15-8-4-13(5-9-15)6-11-20(30)31/h1-12,29H,(H,30,31)/b11-6+	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	5.1	37
Novartis AG US Patent					Assay Description The ER transcription assay is a reporter assay that is based on the ability of ER to induce transcription from a luciferase reporter gene containing ...				US Patent US10058534 (2018) BindingDB Entry DOI: 10.7270/Q2M32XSG
					More data for this Ligand-Target Pair