BDBM269454 (E)-3-(4-((6-hydroxy-2- (2-(2,2,2- trifluoroethyl)phenyl) benzo[b]thiophen-3- yl)oxy)phenyl)acrylic acid::US10058534, 109

SMILES: OC(=O)\C=C\c1ccc(Oc2c(sc3cc(O)ccc23)-c2ccccc2CC(F)(F)F)cc1

InChI Key: InChIKey=LEFRLZCNEVFAQY-KPKJPENVSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 269454   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Estrogen receptor (Homo sapiens (Human))	BDBM269454 ((E)-3-(4-((6-hydroxy-2- (2-(2,2,2- trifluoroethyl)...) Show SMILES OC(=O)\C=C\c1ccc(Oc2c(sc3cc(O)ccc23)-c2ccccc2CC(F)(F)F)cc1 Show InChI InChI=1S/C25H17F3O4S/c26-25(27,28)14-16-3-1-2-4-19(16)24-23(20-11-8-17(29)13-21(20)33-24)32-18-9-5-15(6-10-18)7-12-22(30)31/h1-13,29H,14H2,(H,30,31)/b12-7+	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.4	25
Novartis AG US Patent					Assay Description Plate MCF7 cells at 0.3 million cells/mL (100 l/well) in black, clear-bottom 96-well plates (Greiner, catalog number 655090) in DMEM/F12 media (Gibco...				US Patent US10058534 (2018) BindingDB Entry DOI: 10.7270/Q2M32XSG
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM269454 ((E)-3-(4-((6-hydroxy-2- (2-(2,2,2- trifluoroethyl)...) Show SMILES OC(=O)\C=C\c1ccc(Oc2c(sc3cc(O)ccc23)-c2ccccc2CC(F)(F)F)cc1 Show InChI InChI=1S/C25H17F3O4S/c26-25(27,28)14-16-3-1-2-4-19(16)24-23(20-11-8-17(29)13-21(20)33-24)32-18-9-5-15(6-10-18)7-12-22(30)31/h1-13,29H,14H2,(H,30,31)/b12-7+	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	5.1	37
Novartis AG US Patent					Assay Description The ER transcription assay is a reporter assay that is based on the ability of ER to induce transcription from a luciferase reporter gene containing ...				US Patent US10058534 (2018) BindingDB Entry DOI: 10.7270/Q2M32XSG
					More data for this Ligand-Target Pair