BDBM269485 (S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,3,4,5-tetrahydropyridin-2-yl)-4-fluorophenyl)-5-chloropicolinamide::US10058540, 1
SMILES: NC1=N[C@](CF)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)C(F)(F)CC1
InChI Key: InChIKey=MLHBJYSBEAENRB-QGZVFWFLSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-secretase 1 (Homo sapiens (Human)) | BDBM269485 ( (S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 5.70 | -11.2 | n/a | n/a | n/a | n/a | n/a | 4.5 | 25 |
H. Lundbeck A/S US Patent | Assay Description The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr... | US Patent US10058540 (2018) BindingDB Entry DOI: 10.7270/Q2GB262J | |||||||||||
More data for this Ligand-Target Pair |