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SMILES: [SH-]

InChI Key: InChIKey=RWSOTUBLDIXVET-UHFFFAOYSA-M

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 60 hits for monomerid = 26990   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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600n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibition constant of anion against human carbonic anhydrase isozyme hCA I


Bioorg Med Chem Lett 14: 5769-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.063
BindingDB Entry DOI: 10.7270/Q24X58JJ
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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600n/an/an/an/an/an/an/an/a



Centre Scientifique de Monaco

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay


Bioorg Med Chem Lett 21: 710-4 (2011)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.124
BindingDB Entry DOI: 10.7270/Q26D5T7K
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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600n/an/an/an/an/an/an/an/a



Istituto di Bioscienze e Biorisorse (IBBR)-CNR

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method


Bioorg Med Chem Lett 24: 4389-96 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.015
BindingDB Entry DOI: 10.7270/Q28054D1
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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600n/an/an/an/an/an/an/an/a



Kochi Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant wild type CA1 by stopped-flow CO2 hydration method


Bioorg Med Chem Lett 23: 256-60 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.103
BindingDB Entry DOI: 10.7270/Q2ZC846G
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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600n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay


Bioorg Med Chem Lett 22: 7142-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.065
BindingDB Entry DOI: 10.7270/Q2930VB8
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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600n/an/an/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase-1 by [18O]-exchange mass spectroscopy


Bioorg Med Chem Lett 25: 4937-40 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.001
BindingDB Entry DOI: 10.7270/Q2VQ34GP
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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600n/an/an/an/an/an/a7.5n/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5


Bioorg Med Chem 19: 1847-51 (2011)


Article DOI: 10.1016/j.bmc.2011.02.015
BindingDB Entry DOI: 10.7270/Q2QN672R
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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600n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay


Bioorg Med Chem Lett 23: 1636-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.084
BindingDB Entry DOI: 10.7270/Q2VD70TX
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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600 -8.34n/an/an/an/an/a7.520



Universit£ degli Studi di Firenze



Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay


Bioorg Med Chem 24: 3413-7 (2016)


Article DOI: 10.1016/j.bmc.2016.05.029
BindingDB Entry DOI: 10.7270/Q2W9583B
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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600 -8.34n/an/an/an/an/a7.520



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem Lett 19: 1155-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.082
BindingDB Entry DOI: 10.7270/Q2KD1W79
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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600n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibitory activity against human carbonic anhydrase I expressed in Escherichia coli


Bioorg Med Chem Lett 14: 5435-9 (2004)

Checked by Author
Article DOI: 10.1016/j.bmcl.2004.07.086
BindingDB Entry DOI: 10.7270/Q2SN09QF
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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600n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibitory constant against carbonic anhydrase I


Bioorg Med Chem Lett 14: 4563-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.073
BindingDB Entry DOI: 10.7270/Q2H995ZD
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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600n/an/an/an/an/an/a8.3n/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay at pH 8.3


Bioorg Med Chem Lett 21: 3591-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.105
BindingDB Entry DOI: 10.7270/Q2930TGN
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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600n/an/an/an/an/an/an/an/a



University of Tampere and Tampere University Hospital

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase-1 at 20 degC preincubated for 15 mins by stopped-flow CO2 hydrase assay


Bioorg Med Chem 21: 4472-6 (2013)


Article DOI: 10.1016/j.bmc.2013.05.058
BindingDB Entry DOI: 10.7270/Q28S4SV8
More data for this
Ligand-Target Pair
Carbonic anhydrase, alpha family


(Thiomicrospira crunogena (strain XCL-2))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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1.10E+3n/an/an/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of Thiomicrospira crunogena XCL-2 alpha-carbonic anhydrase expressed in Escherichia coli BL21 (DE3) cells by [18O]-exchange mass spectrosc...


Bioorg Med Chem Lett 25: 4937-40 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.001
BindingDB Entry DOI: 10.7270/Q2VQ34GP
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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2.80E+3n/an/an/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase-2 by [18O]-exchange mass spectroscopy


Bioorg Med Chem Lett 25: 4937-40 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.001
BindingDB Entry DOI: 10.7270/Q2VQ34GP
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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7.00E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibition constant of anion against human carbonic anhydrase isozyme hCA IX


Bioorg Med Chem Lett 14: 5769-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.063
BindingDB Entry DOI: 10.7270/Q24X58JJ
More data for this
Ligand-Target Pair
Carbonic anhydrase 15 [19-324]


(Mus musculus (mouse))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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9.20E+3n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem Lett 19: 1155-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.082
BindingDB Entry DOI: 10.7270/Q2KD1W79
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/an/an/a



Centre Scientifique de Monaco

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay


Bioorg Med Chem Lett 21: 710-4 (2011)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.124
BindingDB Entry DOI: 10.7270/Q26D5T7K
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase-2 by CO2 hydration reaction based colorimetric stopped-flow method


Bioorg Med Chem 23: 4831-8 (2015)


Article DOI: 10.1016/j.bmc.2015.05.029
BindingDB Entry DOI: 10.7270/Q20V8FK8
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method


Bioorg Med Chem Lett 24: 4402-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.014
BindingDB Entry DOI: 10.7270/Q2348N4M
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/an/an/a



Istituto di Bioscienze e Biorisorse (IBBR)-CNR

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method


Bioorg Med Chem Lett 24: 4389-96 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.015
BindingDB Entry DOI: 10.7270/Q28054D1
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/an/an/a



Istituto di Bioscienze e Biorisorse

Curated by ChEMBL


Assay Description
Inhibition of human CA2 after 15 mins by stopped-flow/Co2 hydration assay


Bioorg Med Chem 23: 4405-9 (2015)


Article DOI: 10.1016/j.bmc.2015.06.021
BindingDB Entry DOI: 10.7270/Q2JD4ZJ0
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4 -5.89n/an/an/an/an/a7.520



Universit£ degli Studi di Firenze



Assay Description
Inhibition of Helicobacter pylori alpha carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydrase assay


Bioorg Med Chem 24: 3413-7 (2016)


Article DOI: 10.1016/j.bmc.2016.05.029
BindingDB Entry DOI: 10.7270/Q2W9583B
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem Lett 19: 1155-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.082
BindingDB Entry DOI: 10.7270/Q2KD1W79
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/a7.5n/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5


Bioorg Med Chem 19: 1847-51 (2011)


Article DOI: 10.1016/j.bmc.2011.02.015
BindingDB Entry DOI: 10.7270/Q2QN672R
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/an/an/a



University of Tampere and Tampere University Hospital

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase-2 at 20 degC preincubated for 15 mins by stopped-flow CO2 hydrase assay


Bioorg Med Chem 21: 4472-6 (2013)


Article DOI: 10.1016/j.bmc.2013.05.058
BindingDB Entry DOI: 10.7270/Q28S4SV8
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/an/an/a



Kochi Medical School

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay


Bioorg Med Chem Lett 24: 1127-32 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.124
BindingDB Entry DOI: 10.7270/Q2FX7DDZ
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/an/an/a



CNR

Curated by ChEMBL


Assay Description
Inhibition of human CA2 incubated for 15 mins by stopped-flow CO2 hydration assay


Bioorg Med Chem 25: 4800-4804 (2017)


Article DOI: 10.1016/j.bmc.2017.07.033
BindingDB Entry DOI: 10.7270/Q2028V0P
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/an/an/a



Istituto di Bioscienze e Biorisorse, CNR

Curated by ChEMBL


Assay Description
Inhibition of recombinant human carbonic anhydrase 2 assessed as inhibition of CO2 hydration incubated for 15 mins prior to testing by stopped flow C...


Bioorg Med Chem 25: 2010-2015 (2017)


Article DOI: 10.1016/j.bmc.2017.02.032
BindingDB Entry DOI: 10.7270/Q2JD5012
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/an/an/a



Italy; Universit£ degliStudi di Firenze

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 2 assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method


Bioorg Med Chem 25: 575-580 (2017)


Article DOI: 10.1016/j.bmc.2016.11.021
BindingDB Entry DOI: 10.7270/Q2M047FF
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay


Bioorg Med Chem Lett 22: 7142-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.065
BindingDB Entry DOI: 10.7270/Q2930VB8
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/an/an/a



Kochi Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant wild type CA2 by stopped-flow CO2 hydration method


Bioorg Med Chem Lett 23: 256-60 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.103
BindingDB Entry DOI: 10.7270/Q2ZC846G
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/an/an/a



Istituto di Biochimica delle Proteine (IBP)

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 1465-9 (2013)


Article DOI: 10.1016/j.bmc.2012.09.047
BindingDB Entry DOI: 10.7270/Q20R9QQQ
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay


Bioorg Med Chem Lett 23: 1636-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.084
BindingDB Entry DOI: 10.7270/Q2VD70TX
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/an/an/a



Istituto di Biostrutture e Bioimmagini

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic carbonic anhydrase-2 preincubated for 15 mins by stopped flow CO2 hydration assay


Bioorg Med Chem Lett 23: 1626-30 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.087
BindingDB Entry DOI: 10.7270/Q23X8806
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibition constant of anion against human carbonic anhydrase isozyme hCA II


Bioorg Med Chem Lett 14: 5769-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.063
BindingDB Entry DOI: 10.7270/Q24X58JJ
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coli


Bioorg Med Chem Lett 14: 5435-9 (2004)

Checked by Author
Article DOI: 10.1016/j.bmcl.2004.07.086
BindingDB Entry DOI: 10.7270/Q2SN09QF
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibitory constant against carbonic anhydrase II


Bioorg Med Chem Lett 14: 4563-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.073
BindingDB Entry DOI: 10.7270/Q2H995ZD
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/a8.3n/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay at pH 8.3


Bioorg Med Chem Lett 21: 3591-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.105
BindingDB Entry DOI: 10.7270/Q2930TGN
More data for this
Ligand-Target Pair
Carbonic anhydrase


(Methanosarcina thermophila)
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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5.00E+4n/an/an/an/an/an/an/an/a



Istituto di Biochimica delle Proteine - CNR

Curated by ChEMBL


Assay Description
Inhibition of Methanosarcina thermophila recombinant gamma-CA by CO2 hydration assay


Bioorg Med Chem Lett 23: 4067-71 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.063
BindingDB Entry DOI: 10.7270/Q2HX1F27
More data for this
Ligand-Target Pair
Carbonic anhydrase


(Methanosarcina thermophila)
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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5.00E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibitory constant against Zn-Cam (Methanosarcina thermophila)


Bioorg Med Chem Lett 14: 4563-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.073
BindingDB Entry DOI: 10.7270/Q2H995ZD
More data for this
Ligand-Target Pair
Carbonic anhydrase


(Methanosarcina thermophila)
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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5.00E+4n/an/an/an/an/an/an/an/a



Istituto di Bioscienze e Biorisorse

Curated by ChEMBL


Assay Description
Inhibition of archaeon Methanosarcina thermophila gamma-CA after 15 mins by stopped-flow/Co2 hydration assay


Bioorg Med Chem 23: 4405-9 (2015)


Article DOI: 10.1016/j.bmc.2015.06.021
BindingDB Entry DOI: 10.7270/Q2JD4ZJ0
More data for this
Ligand-Target Pair
Carbonic anhydrase


(Methanosarcina thermophila)
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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5.00E+4n/an/an/an/an/an/an/an/a



Italy; Universit£ degliStudi di Firenze

Curated by ChEMBL


Assay Description
Inhibition of Methanosarcina thermophila recombinant carbonic anhydrase gamma assessed as inhibition of CO2 hydration preincubated for 15 mins by Lin...


Bioorg Med Chem 25: 575-580 (2017)


Article DOI: 10.1016/j.bmc.2016.11.021
BindingDB Entry DOI: 10.7270/Q2M047FF
More data for this
Ligand-Target Pair
Carbonic anhydrase


(Vibrio cholerae serotype O1 (strain ATCC 39315 / E...)
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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7.40E+4 -5.54n/an/an/an/an/a7.520



Universit£ degli Studi di Firenze



Assay Description
Inhibition of Flaveria bidentis carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay


Bioorg Med Chem 24: 3413-7 (2016)


Article DOI: 10.1016/j.bmc.2016.05.029
BindingDB Entry DOI: 10.7270/Q2W9583B
More data for this
Ligand-Target Pair
Carbonic anhydrase


(Astrosclera willeyana)
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.90E+5n/an/an/an/an/an/an/an/a



Slovak Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of Astrosclera willeyana recombinant GST-tagged astrosclerin 3 expressed in Escherichia coli BL21-DE3-RIPL cells preincubated for 15 mins ...


Bioorg Med Chem Lett 22: 1314-6 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.085
BindingDB Entry DOI: 10.7270/Q2W66M7M
More data for this
Ligand-Target Pair
Carbonic anhydrase


(Helicobacter pylori)
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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5.80E+5 -4.41n/an/an/an/an/a7.525



Università degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity Khalifah RG. The carbon dioxide hy...


J Enzyme Inhib Med Chem 28: 388-91 (2013)


Article DOI: 10.3109/14756366.2011.649268
BindingDB Entry DOI: 10.7270/Q2S75F7K
More data for this
Ligand-Target Pair
Carbonic anhydrase


(Stylophora pistillata)
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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5.80E+5n/an/an/an/an/an/an/an/a



Centre Scientifique de Monaco

Curated by ChEMBL


Assay Description
Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay


Bioorg Med Chem Lett 21: 710-4 (2011)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.124
BindingDB Entry DOI: 10.7270/Q26D5T7K
More data for this
Ligand-Target Pair
Carbonic anhydrase


(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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6.20E+5n/an/an/an/an/an/a8.3n/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase-2 by CO2 hydration reaction based colorimetric stopped-flow method


Bioorg Med Chem 23: 4831-8 (2015)


Article DOI: 10.1016/j.bmc.2015.05.029
BindingDB Entry DOI: 10.7270/Q20V8FK8
More data for this
Ligand-Target Pair
Alpha-carbonic anhydrase


(Helicobacter pylori)
BDBM26990
PNG
(CHEMBL1644699 | HS anion | HS(-1) | hydrogen(sulfi...)
Show InChI InChI=1S/H2S/h1H2/p-1
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6.90E+5 -4.31n/an/an/an/an/a7.525



Università degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity Khalifah RG. The carbon dioxide hy...


J Enzyme Inhib Med Chem 28: 388-91 (2013)


Article DOI: 10.3109/14756366.2011.649268
BindingDB Entry DOI: 10.7270/Q2S75F7K
More data for this
Ligand-Target Pair
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