BDBM270505 3-{[((1R)-5-{methyl[4-(methylethyl)phenyl]amino}isoindolinyl)methyl]amino}pyridine-4-carboxylic acid::US10059687, Example 6B

SMILES: CC(C)c1ccc(cc1)N(C)c1ccc2[C@H](CNc3cnccc3C(O)=O)NCc2c1

InChI Key: InChIKey=KCAXPJOFGCTLAL-DEOSSOPVSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 270505   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM270505 (3-{[((1R)-5-{methyl[4-(methylethyl)phenyl]amino}is...) Show SMILES CC(C)c1ccc(cc1)N(C)c1ccc2[C@H](CNc3cnccc3C(O)=O)NCc2c1 |r| Show InChI InChI=1S/C25H28N4O2/c1-16(2)17-4-6-19(7-5-17)29(3)20-8-9-21-18(12-20)13-27-24(21)15-28-23-14-26-11-10-22(23)25(30)31/h4-12,14,16,24,27-28H,13,15H2,1-3H3,(H,30,31)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10059687 (2018) BindingDB Entry DOI: 10.7270/Q2TM7D54
					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM270505 (3-{[((1R)-5-{methyl[4-(methylethyl)phenyl]amino}is...) Show SMILES CC(C)c1ccc(cc1)N(C)c1ccc2[C@H](CNc3cnccc3C(O)=O)NCc2c1 |r| Show InChI InChI=1S/C25H28N4O2/c1-16(2)17-4-6-19(7-5-17)29(3)20-8-9-21-18(12-20)13-27-24(21)15-28-23-14-26-11-10-22(23)25(30)31/h4-12,14,16,24,27-28H,13,15H2,1-3H3,(H,30,31)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...				US Patent US10059687 (2018) BindingDB Entry DOI: 10.7270/Q2TM7D54
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM270505 (3-{[((1R)-5-{methyl[4-(methylethyl)phenyl]amino}is...) Show SMILES CC(C)c1ccc(cc1)N(C)c1ccc2[C@H](CNc3cnccc3C(O)=O)NCc2c1 |r| Show InChI InChI=1S/C25H28N4O2/c1-16(2)17-4-6-19(7-5-17)29(3)20-8-9-21-18(12-20)13-27-24(21)15-28-23-14-26-11-10-22(23)25(30)31/h4-12,14,16,24,27-28H,13,15H2,1-3H3,(H,30,31)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10059687 (2018) BindingDB Entry DOI: 10.7270/Q2TM7D54
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM270505 (3-{[((1R)-5-{methyl[4-(methylethyl)phenyl]amino}is...) Show SMILES CC(C)c1ccc(cc1)N(C)c1ccc2[C@H](CNc3cnccc3C(O)=O)NCc2c1 |r| Show InChI InChI=1S/C25H28N4O2/c1-16(2)17-4-6-19(7-5-17)29(3)20-8-9-21-18(12-20)13-27-24(21)15-28-23-14-26-11-10-22(23)25(30)31/h4-12,14,16,24,27-28H,13,15H2,1-3H3,(H,30,31)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM270505 (3-{[((1R)-5-{methyl[4-(methylethyl)phenyl]amino}is...) Show SMILES CC(C)c1ccc(cc1)N(C)c1ccc2[C@H](CNc3cnccc3C(O)=O)NCc2c1 |r| Show InChI InChI=1S/C25H28N4O2/c1-16(2)17-4-6-19(7-5-17)29(3)20-8-9-21-18(12-20)13-27-24(21)15-28-23-14-26-11-10-22(23)25(30)31/h4-12,14,16,24,27-28H,13,15H2,1-3H3,(H,30,31)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description Jarid1b: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction condit...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM270505 (3-{[((1R)-5-{methyl[4-(methylethyl)phenyl]amino}is...) Show SMILES CC(C)c1ccc(cc1)N(C)c1ccc2[C@H](CNc3cnccc3C(O)=O)NCc2c1 |r| Show InChI InChI=1S/C25H28N4O2/c1-16(2)17-4-6-19(7-5-17)29(3)20-8-9-21-18(12-20)13-27-24(21)15-28-23-14-26-11-10-22(23)25(30)31/h4-12,14,16,24,27-28H,13,15H2,1-3H3,(H,30,31)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description Jarid1b: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction condit...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM270505 (3-{[((1R)-5-{methyl[4-(methylethyl)phenyl]amino}is...) Show SMILES CC(C)c1ccc(cc1)N(C)c1ccc2[C@H](CNc3cnccc3C(O)=O)NCc2c1 |r| Show InChI InChI=1S/C25H28N4O2/c1-16(2)17-4-6-19(7-5-17)29(3)20-8-9-21-18(12-20)13-27-24(21)15-28-23-14-26-11-10-22(23)25(30)31/h4-12,14,16,24,27-28H,13,15H2,1-3H3,(H,30,31)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM270505 (3-{[((1R)-5-{methyl[4-(methylethyl)phenyl]amino}is...) Show SMILES CC(C)c1ccc(cc1)N(C)c1ccc2[C@H](CNc3cnccc3C(O)=O)NCc2c1 |r| Show InChI InChI=1S/C25H28N4O2/c1-16(2)17-4-6-19(7-5-17)29(3)20-8-9-21-18(12-20)13-27-24(21)15-28-23-14-26-11-10-22(23)25(30)31/h4-12,14,16,24,27-28H,13,15H2,1-3H3,(H,30,31)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description JMJD3: The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of t...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM270505 (3-{[((1R)-5-{methyl[4-(methylethyl)phenyl]amino}is...) Show SMILES CC(C)c1ccc(cc1)N(C)c1ccc2[C@H](CNc3cnccc3C(O)=O)NCc2c1 |r| Show InChI InChI=1S/C25H28N4O2/c1-16(2)17-4-6-19(7-5-17)29(3)20-8-9-21-18(12-20)13-27-24(21)15-28-23-14-26-11-10-22(23)25(30)31/h4-12,14,16,24,27-28H,13,15H2,1-3H3,(H,30,31)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description JMJD3: The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of t...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair