BDBM270506 3-[({(1S)-5-[2-methyl-4-(2,2,2-trifluoroethoxy)phenyl]isoindolinyl}methyl)amino]pyridine-4-carboxylic acid::US10059687, Example 7A

SMILES: Cc1cc(OCC(F)(F)F)ccc1-c1ccc2[C@@H](CNc3cnccc3C(O)=O)NCc2c1

InChI Key: InChIKey=WJERCIWKFAXUAX-JOCHJYFZSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 270506   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM270506 (3-[({(1S)-5-[2-methyl-4-(2,2,2-trifluoroethoxy)phe...) Show SMILES Cc1cc(OCC(F)(F)F)ccc1-c1ccc2[C@@H](CNc3cnccc3C(O)=O)NCc2c1 |r| Show InChI InChI=1S/C24H22F3N3O3/c1-14-8-17(33-13-24(25,26)27)3-5-18(14)15-2-4-19-16(9-15)10-29-22(19)12-30-21-11-28-7-6-20(21)23(31)32/h2-9,11,22,29-30H,10,12-13H2,1H3,(H,31,32)/t22-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10059687 (2018) BindingDB Entry DOI: 10.7270/Q2TM7D54
					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM270506 (3-[({(1S)-5-[2-methyl-4-(2,2,2-trifluoroethoxy)phe...) Show SMILES Cc1cc(OCC(F)(F)F)ccc1-c1ccc2[C@@H](CNc3cnccc3C(O)=O)NCc2c1 |r| Show InChI InChI=1S/C24H22F3N3O3/c1-14-8-17(33-13-24(25,26)27)3-5-18(14)15-2-4-19-16(9-15)10-29-22(19)12-30-21-11-28-7-6-20(21)23(31)32/h2-9,11,22,29-30H,10,12-13H2,1H3,(H,31,32)/t22-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...				US Patent US10059687 (2018) BindingDB Entry DOI: 10.7270/Q2TM7D54
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM270506 (3-[({(1S)-5-[2-methyl-4-(2,2,2-trifluoroethoxy)phe...) Show SMILES Cc1cc(OCC(F)(F)F)ccc1-c1ccc2[C@@H](CNc3cnccc3C(O)=O)NCc2c1 |r| Show InChI InChI=1S/C24H22F3N3O3/c1-14-8-17(33-13-24(25,26)27)3-5-18(14)15-2-4-19-16(9-15)10-29-22(19)12-30-21-11-28-7-6-20(21)23(31)32/h2-9,11,22,29-30H,10,12-13H2,1H3,(H,31,32)/t22-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10059687 (2018) BindingDB Entry DOI: 10.7270/Q2TM7D54
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM270506 (3-[({(1S)-5-[2-methyl-4-(2,2,2-trifluoroethoxy)phe...) Show SMILES Cc1cc(OCC(F)(F)F)ccc1-c1ccc2[C@@H](CNc3cnccc3C(O)=O)NCc2c1 |r| Show InChI InChI=1S/C24H22F3N3O3/c1-14-8-17(33-13-24(25,26)27)3-5-18(14)15-2-4-19-16(9-15)10-29-22(19)12-30-21-11-28-7-6-20(21)23(31)32/h2-9,11,22,29-30H,10,12-13H2,1H3,(H,31,32)/t22-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM270506 (3-[({(1S)-5-[2-methyl-4-(2,2,2-trifluoroethoxy)phe...) Show SMILES Cc1cc(OCC(F)(F)F)ccc1-c1ccc2[C@@H](CNc3cnccc3C(O)=O)NCc2c1 |r| Show InChI InChI=1S/C24H22F3N3O3/c1-14-8-17(33-13-24(25,26)27)3-5-18(14)15-2-4-19-16(9-15)10-29-22(19)12-30-21-11-28-7-6-20(21)23(31)32/h2-9,11,22,29-30H,10,12-13H2,1H3,(H,31,32)/t22-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description Jarid1b: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction condit...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM270506 (3-[({(1S)-5-[2-methyl-4-(2,2,2-trifluoroethoxy)phe...) Show SMILES Cc1cc(OCC(F)(F)F)ccc1-c1ccc2[C@@H](CNc3cnccc3C(O)=O)NCc2c1 |r| Show InChI InChI=1S/C24H22F3N3O3/c1-14-8-17(33-13-24(25,26)27)3-5-18(14)15-2-4-19-16(9-15)10-29-22(19)12-30-21-11-28-7-6-20(21)23(31)32/h2-9,11,22,29-30H,10,12-13H2,1H3,(H,31,32)/t22-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description Jarid1b: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction condit...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM270506 (3-[({(1S)-5-[2-methyl-4-(2,2,2-trifluoroethoxy)phe...) Show SMILES Cc1cc(OCC(F)(F)F)ccc1-c1ccc2[C@@H](CNc3cnccc3C(O)=O)NCc2c1 |r| Show InChI InChI=1S/C24H22F3N3O3/c1-14-8-17(33-13-24(25,26)27)3-5-18(14)15-2-4-19-16(9-15)10-29-22(19)12-30-21-11-28-7-6-20(21)23(31)32/h2-9,11,22,29-30H,10,12-13H2,1H3,(H,31,32)/t22-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM270506 (3-[({(1S)-5-[2-methyl-4-(2,2,2-trifluoroethoxy)phe...) Show SMILES Cc1cc(OCC(F)(F)F)ccc1-c1ccc2[C@@H](CNc3cnccc3C(O)=O)NCc2c1 |r| Show InChI InChI=1S/C24H22F3N3O3/c1-14-8-17(33-13-24(25,26)27)3-5-18(14)15-2-4-19-16(9-15)10-29-22(19)12-30-21-11-28-7-6-20(21)23(31)32/h2-9,11,22,29-30H,10,12-13H2,1H3,(H,31,32)/t22-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description JMJD3: The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of t...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM270506 (3-[({(1S)-5-[2-methyl-4-(2,2,2-trifluoroethoxy)phe...) Show SMILES Cc1cc(OCC(F)(F)F)ccc1-c1ccc2[C@@H](CNc3cnccc3C(O)=O)NCc2c1 |r| Show InChI InChI=1S/C24H22F3N3O3/c1-14-8-17(33-13-24(25,26)27)3-5-18(14)15-2-4-19-16(9-15)10-29-22(19)12-30-21-11-28-7-6-20(21)23(31)32/h2-9,11,22,29-30H,10,12-13H2,1H3,(H,31,32)/t22-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description JMJD3: The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of t...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair