BDBM270527 (S)-3-(((6-(2,6-dimethylphenyl)-2-methyl-1,2,3,4-tetra-hydroisoquinolin-1-yl)methyl)amino)isonicotinic acid::US10059687, Example 17B

SMILES: CN1CCc2cc(ccc2[C@H]1CNc1cnccc1C(O)=O)-c1c(C)cccc1C

InChI Key: InChIKey=RPSPFNDBMKKWBL-HSZRJFAPSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 270527   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM270527 ((S)-3-(((6-(2,6-dimethylphenyl)-2-methyl-1,2,3,4-t...) Show SMILES CN1CCc2cc(ccc2[C@H]1CNc1cnccc1C(O)=O)-c1c(C)cccc1C |r| Show InChI InChI=1S/C25H27N3O2/c1-16-5-4-6-17(2)24(16)19-7-8-20-18(13-19)10-12-28(3)23(20)15-27-22-14-26-11-9-21(22)25(29)30/h4-9,11,13-14,23,27H,10,12,15H2,1-3H3,(H,29,30)/t23-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10059687 (2018) BindingDB Entry DOI: 10.7270/Q2TM7D54
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM270527 ((S)-3-(((6-(2,6-dimethylphenyl)-2-methyl-1,2,3,4-t...) Show SMILES CN1CCc2cc(ccc2[C@H]1CNc1cnccc1C(O)=O)-c1c(C)cccc1C |r| Show InChI InChI=1S/C25H27N3O2/c1-16-5-4-6-17(2)24(16)19-7-8-20-18(13-19)10-12-28(3)23(20)15-27-22-14-26-11-9-21(22)25(29)30/h4-9,11,13-14,23,27H,10,12,15H2,1-3H3,(H,29,30)/t23-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description Jarid1b: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction condit...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM270527 ((S)-3-(((6-(2,6-dimethylphenyl)-2-methyl-1,2,3,4-t...) Show SMILES CN1CCc2cc(ccc2[C@H]1CNc1cnccc1C(O)=O)-c1c(C)cccc1C |r| Show InChI InChI=1S/C25H27N3O2/c1-16-5-4-6-17(2)24(16)19-7-8-20-18(13-19)10-12-28(3)23(20)15-27-22-14-26-11-9-21(22)25(29)30/h4-9,11,13-14,23,27H,10,12,15H2,1-3H3,(H,29,30)/t23-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM270527 ((S)-3-(((6-(2,6-dimethylphenyl)-2-methyl-1,2,3,4-t...) Show SMILES CN1CCc2cc(ccc2[C@H]1CNc1cnccc1C(O)=O)-c1c(C)cccc1C |r| Show InChI InChI=1S/C25H27N3O2/c1-16-5-4-6-17(2)24(16)19-7-8-20-18(13-19)10-12-28(3)23(20)15-27-22-14-26-11-9-21(22)25(29)30/h4-9,11,13-14,23,27H,10,12,15H2,1-3H3,(H,29,30)/t23-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10059687 (2018) BindingDB Entry DOI: 10.7270/Q2TM7D54
					More data for this Ligand-Target Pair