BDBM270533 (S)-3-(((2-methyl-5-(methyl(4-propylphenyl)amino)isoindolin-1-yl)methyl)amino)isonicotinic acid::US10059687, Example 20B

SMILES: CCCc1ccc(cc1)N(C)c1ccc2[C@@H](CNc3cnccc3C(O)=O)N(C)Cc2c1

InChI Key: InChIKey=FVXXFMCNHUPXTQ-RUZDIDTESA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 270533   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM270533 ((S)-3-(((2-methyl-5-(methyl(4-propylphenyl)amino)i...) Show SMILES CCCc1ccc(cc1)N(C)c1ccc2[C@@H](CNc3cnccc3C(O)=O)N(C)Cc2c1 |r| Show InChI InChI=1S/C26H30N4O2/c1-4-5-18-6-8-20(9-7-18)30(3)21-10-11-22-19(14-21)17-29(2)25(22)16-28-24-15-27-13-12-23(24)26(31)32/h6-15,25,28H,4-5,16-17H2,1-3H3,(H,31,32)/t25-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10059687 (2018) BindingDB Entry DOI: 10.7270/Q2TM7D54
					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM270533 ((S)-3-(((2-methyl-5-(methyl(4-propylphenyl)amino)i...) Show SMILES CCCc1ccc(cc1)N(C)c1ccc2[C@@H](CNc3cnccc3C(O)=O)N(C)Cc2c1 |r| Show InChI InChI=1S/C26H30N4O2/c1-4-5-18-6-8-20(9-7-18)30(3)21-10-11-22-19(14-21)17-29(2)25(22)16-28-24-15-27-13-12-23(24)26(31)32/h6-15,25,28H,4-5,16-17H2,1-3H3,(H,31,32)/t25-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...				US Patent US10059687 (2018) BindingDB Entry DOI: 10.7270/Q2TM7D54
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM270533 ((S)-3-(((2-methyl-5-(methyl(4-propylphenyl)amino)i...) Show SMILES CCCc1ccc(cc1)N(C)c1ccc2[C@@H](CNc3cnccc3C(O)=O)N(C)Cc2c1 |r| Show InChI InChI=1S/C26H30N4O2/c1-4-5-18-6-8-20(9-7-18)30(3)21-10-11-22-19(14-21)17-29(2)25(22)16-28-24-15-27-13-12-23(24)26(31)32/h6-15,25,28H,4-5,16-17H2,1-3H3,(H,31,32)/t25-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description Jarid1b: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction condit...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM270533 ((S)-3-(((2-methyl-5-(methyl(4-propylphenyl)amino)i...) Show SMILES CCCc1ccc(cc1)N(C)c1ccc2[C@@H](CNc3cnccc3C(O)=O)N(C)Cc2c1 |r| Show InChI InChI=1S/C26H30N4O2/c1-4-5-18-6-8-20(9-7-18)30(3)21-10-11-22-19(14-21)17-29(2)25(22)16-28-24-15-27-13-12-23(24)26(31)32/h6-15,25,28H,4-5,16-17H2,1-3H3,(H,31,32)/t25-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM270533 ((S)-3-(((2-methyl-5-(methyl(4-propylphenyl)amino)i...) Show SMILES CCCc1ccc(cc1)N(C)c1ccc2[C@@H](CNc3cnccc3C(O)=O)N(C)Cc2c1 |r| Show InChI InChI=1S/C26H30N4O2/c1-4-5-18-6-8-20(9-7-18)30(3)21-10-11-22-19(14-21)17-29(2)25(22)16-28-24-15-27-13-12-23(24)26(31)32/h6-15,25,28H,4-5,16-17H2,1-3H3,(H,31,32)/t25-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description JMJD3: The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of t...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM270533 ((S)-3-(((2-methyl-5-(methyl(4-propylphenyl)amino)i...) Show SMILES CCCc1ccc(cc1)N(C)c1ccc2[C@@H](CNc3cnccc3C(O)=O)N(C)Cc2c1 |r| Show InChI InChI=1S/C26H30N4O2/c1-4-5-18-6-8-20(9-7-18)30(3)21-10-11-22-19(14-21)17-29(2)25(22)16-28-24-15-27-13-12-23(24)26(31)32/h6-15,25,28H,4-5,16-17H2,1-3H3,(H,31,32)/t25-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10059687 (2018) BindingDB Entry DOI: 10.7270/Q2TM7D54
					More data for this Ligand-Target Pair