BDBM270535 (S)-3-(((2-methyl-5-(o-tolyl)iso-indolin-1-yl)methyl)amino) isonicotinic acid::US10059687, Example 21B

SMILES: CN1Cc2cc(ccc2[C@H]1CNc1cnccc1C(O)=O)-c1ccccc1C

InChI Key: InChIKey=VWCIJAQHQIPQCH-JOCHJYFZSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 270535   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM270535 ((S)-3-(((2-methyl-5-(o-tolyl)iso-indolin-1-yl)meth...) Show SMILES CN1Cc2cc(ccc2[C@H]1CNc1cnccc1C(O)=O)-c1ccccc1C |r| Show InChI InChI=1S/C23H23N3O2/c1-15-5-3-4-6-18(15)16-7-8-19-17(11-16)14-26(2)22(19)13-25-21-12-24-10-9-20(21)23(27)28/h3-12,22,25H,13-14H2,1-2H3,(H,27,28)/t22-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10059687 (2018) BindingDB Entry DOI: 10.7270/Q2TM7D54
					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM270535 ((S)-3-(((2-methyl-5-(o-tolyl)iso-indolin-1-yl)meth...) Show SMILES CN1Cc2cc(ccc2[C@H]1CNc1cnccc1C(O)=O)-c1ccccc1C |r| Show InChI InChI=1S/C23H23N3O2/c1-15-5-3-4-6-18(15)16-7-8-19-17(11-16)14-26(2)22(19)13-25-21-12-24-10-9-20(21)23(27)28/h3-12,22,25H,13-14H2,1-2H3,(H,27,28)/t22-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...				US Patent US10059687 (2018) BindingDB Entry DOI: 10.7270/Q2TM7D54
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM270535 ((S)-3-(((2-methyl-5-(o-tolyl)iso-indolin-1-yl)meth...) Show SMILES CN1Cc2cc(ccc2[C@H]1CNc1cnccc1C(O)=O)-c1ccccc1C |r| Show InChI InChI=1S/C23H23N3O2/c1-15-5-3-4-6-18(15)16-7-8-19-17(11-16)14-26(2)22(19)13-25-21-12-24-10-9-20(21)23(27)28/h3-12,22,25H,13-14H2,1-2H3,(H,27,28)/t22-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description Jarid1b: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction condit...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM270535 ((S)-3-(((2-methyl-5-(o-tolyl)iso-indolin-1-yl)meth...) Show SMILES CN1Cc2cc(ccc2[C@H]1CNc1cnccc1C(O)=O)-c1ccccc1C |r| Show InChI InChI=1S/C23H23N3O2/c1-15-5-3-4-6-18(15)16-7-8-19-17(11-16)14-26(2)22(19)13-25-21-12-24-10-9-20(21)23(27)28/h3-12,22,25H,13-14H2,1-2H3,(H,27,28)/t22-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM270535 ((S)-3-(((2-methyl-5-(o-tolyl)iso-indolin-1-yl)meth...) Show SMILES CN1Cc2cc(ccc2[C@H]1CNc1cnccc1C(O)=O)-c1ccccc1C |r| Show InChI InChI=1S/C23H23N3O2/c1-15-5-3-4-6-18(15)16-7-8-19-17(11-16)14-26(2)22(19)13-25-21-12-24-10-9-20(21)23(27)28/h3-12,22,25H,13-14H2,1-2H3,(H,27,28)/t22-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description JMJD3: The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of t...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM270535 ((S)-3-(((2-methyl-5-(o-tolyl)iso-indolin-1-yl)meth...) Show SMILES CN1Cc2cc(ccc2[C@H]1CNc1cnccc1C(O)=O)-c1ccccc1C |r| Show InChI InChI=1S/C23H23N3O2/c1-15-5-3-4-6-18(15)16-7-8-19-17(11-16)14-26(2)22(19)13-25-21-12-24-10-9-20(21)23(27)28/h3-12,22,25H,13-14H2,1-2H3,(H,27,28)/t22-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10059687 (2018) BindingDB Entry DOI: 10.7270/Q2TM7D54
					More data for this Ligand-Target Pair