null

SMILES: CC(C)(C)CNc1ncnc2ccc(N[C@H](c3cn(nn3)C3CC3)c3ccccc3Cl)cc12

InChI Key: InChIKey=KKQZQORNQXJZDZ-QHCPKHFHSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 270576   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270576 ((S)-N6-((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3...) Show SMILES CC(C)(C)CNc1ncnc2ccc(N[C@H](c3cn(nn3)C3CC3)c3ccccc3Cl)cc12 |r| Show InChI InChI=1S/C25H28ClN7/c1-25(2,3)14-27-24-19-12-16(8-11-21(19)28-15-29-24)30-23(18-6-4-5-7-20(18)26)22-13-33(32-31-22)17-9-10-17/h4-8,11-13,15,17,23,30H,9-10,14H2,1-3H3,(H,27,28,29)/t23-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270576 ((S)-N6-((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3...) Show SMILES CC(C)(C)CNc1ncnc2ccc(N[C@H](c3cn(nn3)C3CC3)c3ccccc3Cl)cc12 |r| Show InChI InChI=1S/C25H28ClN7/c1-25(2,3)14-27-24-19-12-16(8-11-21(19)28-15-29-24)30-23(18-6-4-5-7-20(18)26)22-13-33(32-31-22)17-9-10-17/h4-8,11-13,15,17,23,30H,9-10,14H2,1-3H3,(H,27,28,29)/t23-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	169	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270576 ((S)-N6-((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3...) Show SMILES CC(C)(C)CNc1ncnc2ccc(N[C@H](c3cn(nn3)C3CC3)c3ccccc3Cl)cc12 |r| Show InChI InChI=1S/C25H28ClN7/c1-25(2,3)14-27-24-19-12-16(8-11-21(19)28-15-29-24)30-23(18-6-4-5-7-20(18)26)22-13-33(32-31-22)17-9-10-17/h4-8,11-13,15,17,23,30H,9-10,14H2,1-3H3,(H,27,28,29)/t23-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270576 ((S)-N6-((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3...) Show SMILES CC(C)(C)CNc1ncnc2ccc(N[C@H](c3cn(nn3)C3CC3)c3ccccc3Cl)cc12 |r| Show InChI InChI=1S/C25H28ClN7/c1-25(2,3)14-27-24-19-12-16(8-11-21(19)28-15-29-24)30-23(18-6-4-5-7-20(18)26)22-13-33(32-31-22)17-9-10-17/h4-8,11-13,15,17,23,30H,9-10,14H2,1-3H3,(H,27,28,29)/t23-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	169	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair