BDBM270587 (S)-6-(((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3-triazol-4- yl)methyl-d)amino)- 4- (neopentylamino) quinazoline-8- carbonitrile::US10059695, I-19::US10577352, Compound I-19

SMILES: CC(C)(C)CNc1ncnc2c(cc(NC(c3cn(nn3)C3CC3)c3ccccc3Cl)cc12)C#N

InChI Key: InChIKey=QUJUDJTWSXMGFT-UHFFFAOYSA-N

Data: 2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 270587   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270587 ((S)-6-(((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3...) Show SMILES CC(C)(C)CNc1ncnc2c(cc(NC(c3cn(nn3)C3CC3)c3ccccc3Cl)cc12)C#N Show InChI InChI=1S/C26H27ClN8/c1-26(2,3)14-29-25-20-11-17(10-16(12-28)23(20)30-15-31-25)32-24(19-6-4-5-7-21(19)27)22-13-35(34-33-22)18-8-9-18/h4-7,10-11,13,15,18,24,32H,8-9,14H2,1-3H3,(H,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270587 ((S)-6-(((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3...) Show SMILES CC(C)(C)CNc1ncnc2c(cc(NC(c3cn(nn3)C3CC3)c3ccccc3Cl)cc12)C#N Show InChI InChI=1S/C26H27ClN8/c1-26(2,3)14-29-25-20-11-17(10-16(12-28)23(20)30-15-31-25)32-24(19-6-4-5-7-21(19)27)22-13-35(34-33-22)18-8-9-18/h4-7,10-11,13,15,18,24,32H,8-9,14H2,1-3H3,(H,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270587 ((S)-6-(((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3...) Show SMILES CC(C)(C)CNc1ncnc2c(cc(NC(c3cn(nn3)C3CC3)c3ccccc3Cl)cc12)C#N Show InChI InChI=1S/C26H27ClN8/c1-26(2,3)14-29-25-20-11-17(10-16(12-28)23(20)30-15-31-25)32-24(19-6-4-5-7-21(19)27)22-13-35(34-33-22)18-8-9-18/h4-7,10-11,13,15,18,24,32H,8-9,14H2,1-3H3,(H,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270587 ((S)-6-(((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3...) Show SMILES CC(C)(C)CNc1ncnc2c(cc(NC(c3cn(nn3)C3CC3)c3ccccc3Cl)cc12)C#N Show InChI InChI=1S/C26H27ClN8/c1-26(2,3)14-29-25-20-11-17(10-16(12-28)23(20)30-15-31-25)32-24(19-6-4-5-7-21(19)27)22-13-35(34-33-22)18-8-9-18/h4-7,10-11,13,15,18,24,32H,8-9,14H2,1-3H3,(H,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	20	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair