BDBM270597 8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((1-(1- ethylpiperidin-4-yl)- 1H-1,2,3-triazol-4- yl)(phenyl)methyl) quinazoline-4,6- diamine::US10059695, II-3::US10577352, Compound II-3

SMILES: CCN1CCC(CC1)n1cc(nn1)C(Nc1cc(Cl)c2ncnc(Nc3ccc(F)c(Cl)c3)c2c1)c1ccccc1

InChI Key: InChIKey=BGNGGPVTCBTSPQ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 270597   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270597 (8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((1-(1...) Show SMILES CCN1CCC(CC1)n1cc(nn1)C(Nc1cc(Cl)c2ncnc(Nc3ccc(F)c(Cl)c3)c2c1)c1ccccc1 Show InChI InChI=1S/C30H29Cl2FN8/c1-2-40-12-10-22(11-13-40)41-17-27(38-39-41)28(19-6-4-3-5-7-19)36-21-14-23-29(25(32)16-21)34-18-35-30(23)37-20-8-9-26(33)24(31)15-20/h3-9,14-18,22,28,36H,2,10-13H2,1H3,(H,34,35,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270597 (8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((1-(1...) Show SMILES CCN1CCC(CC1)n1cc(nn1)C(Nc1cc(Cl)c2ncnc(Nc3ccc(F)c(Cl)c3)c2c1)c1ccccc1 Show InChI InChI=1S/C30H29Cl2FN8/c1-2-40-12-10-22(11-13-40)41-17-27(38-39-41)28(19-6-4-3-5-7-19)36-21-14-23-29(25(32)16-21)34-18-35-30(23)37-20-8-9-26(33)24(31)15-20/h3-9,14-18,22,28,36H,2,10-13H2,1H3,(H,34,35,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair