BDBM270600 (S)-N4-(3-chloro-4- fluorophenyl)-N6- ((4-chlorophenyl)(1- (piperidin-4-yl)-1H- 1,2,3-triazol-4- yl)methyl) quinazoline- 4,6-diamine::US10059695, II-6::US10577352, Compound II-6

SMILES: Fc1ccc(Nc2ncnc3ccc(N[C@H](c4cn(nn4)C4CCNCC4)c4ccc(Cl)cc4)cc23)cc1Cl

InChI Key: InChIKey=TZWDKKCSGGQCCI-MHZLTWQESA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 270600   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270600 ((S)-N4-(3-chloro-4- fluorophenyl)-N6- ((4-chloroph...) Show SMILES Fc1ccc(Nc2ncnc3ccc(N[C@H](c4cn(nn4)C4CCNCC4)c4ccc(Cl)cc4)cc23)cc1Cl |r| Show InChI InChI=1S/C28H25Cl2FN8/c29-18-3-1-17(2-4-18)27(26-15-39(38-37-26)21-9-11-32-12-10-21)35-19-6-8-25-22(13-19)28(34-16-33-25)36-20-5-7-24(31)23(30)14-20/h1-8,13-16,21,27,32,35H,9-12H2,(H,33,34,36)/t27-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270600 ((S)-N4-(3-chloro-4- fluorophenyl)-N6- ((4-chloroph...) Show SMILES Fc1ccc(Nc2ncnc3ccc(N[C@H](c4cn(nn4)C4CCNCC4)c4ccc(Cl)cc4)cc23)cc1Cl |r| Show InChI InChI=1S/C28H25Cl2FN8/c29-18-3-1-17(2-4-18)27(26-15-39(38-37-26)21-9-11-32-12-10-21)35-19-6-8-25-22(13-19)28(34-16-33-25)36-20-5-7-24(31)23(30)14-20/h1-8,13-16,21,27,32,35H,9-12H2,(H,33,34,36)/t27-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	49	n/a	n/a	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair