BDBM270602 (S)-N4-(3-chloro-4- fluorophenyl)-N6- ((4-chlorophenyl)(1- (1-(oxetan-3- yl)piperidin-4-yl)- 1H-1,2,3-triazol-4- yl)methyl) quinazoline- 4,6-diamine::US10059695, II-8::US10577352, Compound II-8
SMILES: Fc1ccc(Nc2ncnc3ccc(N[C@H](c4cn(nn4)C4CCN(CC4)C4COC4)c4ccc(Cl)cc4)cc23)cc1Cl
InChI Key: InChIKey=YLLXLXBKQWDCEB-PMERELPUSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM270602 ((S)-N4-(3-chloro-4- fluorophenyl)-N6- ((4-chloroph...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 318 | n/a | n/a | n/a | n/a | 7.0 | 25 |
GILEAD SCIENCES, INC. US Patent | Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-... | US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM270602 ((S)-N4-(3-chloro-4- fluorophenyl)-N6- ((4-chloroph...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1.24E+3 | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc. US Patent | Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-... | US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM270602 ((S)-N4-(3-chloro-4- fluorophenyl)-N6- ((4-chloroph...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 318 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc. US Patent | Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-... | US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM270602 ((S)-N4-(3-chloro-4- fluorophenyl)-N6- ((4-chloroph...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1.24E+3 | n/a | n/a | 7.0 | 25 |
GILEAD SCIENCES, INC. US Patent | Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-... | US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6 | |||||||||||
More data for this Ligand-Target Pair |