null

SMILES: Fc1ccc(cc1)C(Nc1ccc2ncnc(Nc3cnc(F)c(F)c3)c2c1)c1cn(nn1)C1CC1

InChI Key: InChIKey=CAEMCCZMBSKRRO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 270605   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270605 ((S)-N6-((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...) Show SMILES Fc1ccc(cc1)C(Nc1ccc2ncnc(Nc3cnc(F)c(F)c3)c2c1)c1cn(nn1)C1CC1 Show InChI InChI=1S/C25H19F3N8/c26-15-3-1-14(2-4-15)23(22-12-36(35-34-22)18-6-7-18)32-16-5-8-21-19(9-16)25(31-13-30-21)33-17-10-20(27)24(28)29-11-17/h1-5,8-13,18,23,32H,6-7H2,(H,30,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	74	n/a	n/a	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270605 ((S)-N6-((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...) Show SMILES Fc1ccc(cc1)C(Nc1ccc2ncnc(Nc3cnc(F)c(F)c3)c2c1)c1cn(nn1)C1CC1 Show InChI InChI=1S/C25H19F3N8/c26-15-3-1-14(2-4-15)23(22-12-36(35-34-22)18-6-7-18)32-16-5-8-21-19(9-16)25(31-13-30-21)33-17-10-20(27)24(28)29-11-17/h1-5,8-13,18,23,32H,6-7H2,(H,30,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	645	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270605 ((S)-N6-((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...) Show SMILES Fc1ccc(cc1)C(Nc1ccc2ncnc(Nc3cnc(F)c(F)c3)c2c1)c1cn(nn1)C1CC1 Show InChI InChI=1S/C25H19F3N8/c26-15-3-1-14(2-4-15)23(22-12-36(35-34-22)18-6-7-18)32-16-5-8-21-19(9-16)25(31-13-30-21)33-17-10-20(27)24(28)29-11-17/h1-5,8-13,18,23,32H,6-7H2,(H,30,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270605 ((S)-N6-((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...) Show SMILES Fc1ccc(cc1)C(Nc1ccc2ncnc(Nc3cnc(F)c(F)c3)c2c1)c1cn(nn1)C1CC1 Show InChI InChI=1S/C25H19F3N8/c26-15-3-1-14(2-4-15)23(22-12-36(35-34-22)18-6-7-18)32-16-5-8-21-19(9-16)25(31-13-30-21)33-17-10-20(27)24(28)29-11-17/h1-5,8-13,18,23,32H,6-7H2,(H,30,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	645	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair