BDBM272143 (R)-5-(3-Fluoro-2-methylphenyl)-3-(4-fluorophenyl)- N-hydroxy-2-methyl-2,4,5,6- tetrahydrocyclopenta[c]pyrazole-5-carboxamide::US10065948, 79::US10457675, Example 79

SMILES: Cc1c(F)cccc1[C@@]1(Cc2nn(C)c(c2C1)-c1ccc(F)cc1)C(=O)NO

InChI Key: InChIKey=QOBAYSZNUZHZBS-OAQYLSRUSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 272143   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 9 (Homo sapiens (Human))	BDBM272143 ((R)-5-(3-Fluoro-2-methylphenyl)-3-(4-fluorophenyl)...) Show SMILES Cc1c(F)cccc1[C@@]1(Cc2nn(C)c(c2C1)-c1ccc(F)cc1)C(=O)NO |r| Show InChI InChI=1S/C21H19F2N3O2/c1-12-16(4-3-5-17(12)23)21(20(27)25-28)10-15-18(11-21)24-26(2)19(15)13-6-8-14(22)9-7-13/h3-9,28H,10-11H2,1-2H3,(H,25,27)/t21-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
CHDI Foundation, Inc. US Patent					Assay Description The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...				US Patent US10457675 (2019) BindingDB Entry DOI: 10.7270/Q22J6F7J
					More data for this Ligand-Target Pair
Histone deacetylase 9 (Homo sapiens (Human))	BDBM272143 ((R)-5-(3-Fluoro-2-methylphenyl)-3-(4-fluorophenyl)...) Show SMILES Cc1c(F)cccc1[C@@]1(Cc2nn(C)c(c2C1)-c1ccc(F)cc1)C(=O)NO |r| Show InChI InChI=1S/C21H19F2N3O2/c1-12-16(4-3-5-17(12)23)21(20(27)25-28)10-15-18(11-21)24-26(2)19(15)13-6-8-14(22)9-7-13/h3-9,28H,10-11H2,1-2H3,(H,25,27)/t21-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
CHDI Foundation, Inc. US Patent					Assay Description The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...				US Patent US10065948 (2018) BindingDB Entry DOI: 10.7270/Q2154K23
					More data for this Ligand-Target Pair