BDBM273040 (R)-2-[5-(3-methyloxetan-3-yl)-7-oxo-6,7-dihydro[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-1-carboxylic acid phenyl ester::US10065972, Example 116
SMILES: CC1(COC1)c1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1
InChI Key: InChIKey=WHILANCCPYUUIZ-CYBMUJFWSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (Homo sapiens (Human)) | BDBM273040 ((R)-2-[5-(3-methyloxetan-3-yl)-7-oxo-6,7-dihydro[1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | 8.0 | n/a |
MITSUBISHI TANABE PHARMA CORPORATION US Patent | Assay Description The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont... | US Patent US10065972 (2018) BindingDB Entry DOI: 10.7270/Q23X88P5 | |||||||||||
More data for this Ligand-Target Pair |