BDBM273084 (R)-N-benzyl-1-(6-cyclopentyl-7-oxo-6,7-dihydro-[1,3]thiazolo[5,4-d]pyrimidin-2-yl)pyrrolidine-2-carboxamide::US10065972, Example 238

SMILES: O=C(NCc1ccccc1)[C@H]1CCCN1c1nc2c(ncn(C3CCCC3)c2=O)s1

InChI Key: InChIKey=KHZUIXRRCCNRHG-QGZVFWFLSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273084   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (Homo sapiens (Human))	BDBM273084 ((R)-N-benzyl-1-(6-cyclopentyl-7-oxo-6,7-dihydro-[1...) Show SMILES O=C(NCc1ccccc1)[C@H]1CCCN1c1nc2c(ncn(C3CCCC3)c2=O)s1 |r| Show InChI InChI=1S/C22H25N5O2S/c28-19(23-13-15-7-2-1-3-8-15)17-11-6-12-26(17)22-25-18-20(30-22)24-14-27(21(18)29)16-9-4-5-10-16/h1-3,7-8,14,16-17H,4-6,9-13H2,(H,23,28)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	8.0	n/a
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...				US Patent US10065972 (2018) BindingDB Entry DOI: 10.7270/Q23X88P5
					More data for this Ligand-Target Pair