BDBM273091 (R)-N-benzyl-1-[6-methyl-7-oxo-5-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide::US10065972, Example 259
SMILES: Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)C1CCOCC1
InChI Key: InChIKey=FYUIPOUZYCBCCU-QGZVFWFLSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (Homo sapiens (Human)) | BDBM273091 ((R)-N-benzyl-1-[6-methyl-7-oxo-5-(tetrahydro-2H-py...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | 8.0 | n/a |
MITSUBISHI TANABE PHARMA CORPORATION US Patent | Assay Description The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont... | US Patent US10065972 (2018) BindingDB Entry DOI: 10.7270/Q23X88P5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |