BDBM273130 (R)-N-benzyl-2-{N'-[5-(propan-2-yl)-7-oxo-6,7-dihydro[1,3]thiazolo[5,4-d]pyrimidin-2-yl]-N'-methylamino}propionamide::US10065972, Example 486

SMILES: CC(C)c1nc2sc(nc2c(=O)[nH]1)N(C)[C@H](C)C(=O)NCc1ccccc1

InChI Key: InChIKey=FHDMFRJJYCYFSU-GFCCVEGCSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273130   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (Homo sapiens (Human))	BDBM273130 ((R)-N-benzyl-2-{N'-[5-(propan-2-yl)-7-oxo-6,7-dihy...) Show SMILES CC(C)c1nc2sc(nc2c(=O)[nH]1)N(C)[C@H](C)C(=O)NCc1ccccc1 |r| Show InChI InChI=1S/C19H23N5O2S/c1-11(2)15-22-17(26)14-18(23-15)27-19(21-14)24(4)12(3)16(25)20-10-13-8-6-5-7-9-13/h5-9,11-12H,10H2,1-4H3,(H,20,25)(H,22,23,26)/t12-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	8.0	n/a
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...				US Patent US10065972 (2018) BindingDB Entry DOI: 10.7270/Q23X88P5
					More data for this Ligand-Target Pair