BDBM273251 2-(4-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide::US10071079, Example 25::US10478424, Example 25

SMILES: COc1cc(cn2ncnc12)-c1[nH]c2ccc(cc2c1C(C)C)C1CCN(CC(=O)N(C)C)CC1

InChI Key: InChIKey=ZNEVSKCEHMICQH-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 273251   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 7 (Homo sapiens (Human))	BDBM273251 (2-(4-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5...) Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2ccc(cc2c1C(C)C)C1CCN(CC(=O)N(C)C)CC1 Show InChI InChI=1S/C27H34N6O2/c1-17(2)25-21-12-19(18-8-10-32(11-9-18)15-24(34)31(3)4)6-7-22(21)30-26(25)20-13-23(35-5)27-28-16-29-33(27)14-20/h6-7,12-14,16-18,30H,8-11,15H2,1-5H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10071079 (2018) BindingDB Entry DOI: 10.7270/Q2VD71GV
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM273251 (2-(4-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5...) Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2ccc(cc2c1C(C)C)C1CCN(CC(=O)N(C)C)CC1 Show InChI InChI=1S/C27H34N6O2/c1-17(2)25-21-12-19(18-8-10-32(11-9-18)15-24(34)31(3)4)6-7-22(21)30-26(25)20-13-23(35-5)27-28-16-29-33(27)14-20/h6-7,12-14,16-18,30H,8-11,15H2,1-5H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10071079 (2018) BindingDB Entry DOI: 10.7270/Q2VD71GV
					More data for this Ligand-Target Pair
Toll-like receptor 9 (Homo sapiens (Human))	BDBM273251 (2-(4-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5...) Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2ccc(cc2c1C(C)C)C1CCN(CC(=O)N(C)C)CC1 Show InChI InChI=1S/C27H34N6O2/c1-17(2)25-21-12-19(18-8-10-32(11-9-18)15-24(34)31(3)4)6-7-22(21)30-26(25)20-13-23(35-5)27-28-16-29-33(27)14-20/h6-7,12-14,16-18,30H,8-11,15H2,1-5H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.43E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10478424 (2019) BindingDB Entry DOI: 10.7270/Q2QZ2DB0
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM273251 (2-(4-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5...) Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2ccc(cc2c1C(C)C)C1CCN(CC(=O)N(C)C)CC1 Show InChI InChI=1S/C27H34N6O2/c1-17(2)25-21-12-19(18-8-10-32(11-9-18)15-24(34)31(3)4)6-7-22(21)30-26(25)20-13-23(35-5)27-28-16-29-33(27)14-20/h6-7,12-14,16-18,30H,8-11,15H2,1-5H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10478424 (2019) BindingDB Entry DOI: 10.7270/Q2QZ2DB0
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM273251 (2-(4-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5...) Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2ccc(cc2c1C(C)C)C1CCN(CC(=O)N(C)C)CC1 Show InChI InChI=1S/C27H34N6O2/c1-17(2)25-21-12-19(18-8-10-32(11-9-18)15-24(34)31(3)4)6-7-22(21)30-26(25)20-13-23(35-5)27-28-16-29-33(27)14-20/h6-7,12-14,16-18,30H,8-11,15H2,1-5H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10478424 (2019) BindingDB Entry DOI: 10.7270/Q2QZ2DB0
					More data for this Ligand-Target Pair
Toll-like receptor 9 (Homo sapiens (Human))	BDBM273251 (2-(4-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5...) Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2ccc(cc2c1C(C)C)C1CCN(CC(=O)N(C)C)CC1 Show InChI InChI=1S/C27H34N6O2/c1-17(2)25-21-12-19(18-8-10-32(11-9-18)15-24(34)31(3)4)6-7-22(21)30-26(25)20-13-23(35-5)27-28-16-29-33(27)14-20/h6-7,12-14,16-18,30H,8-11,15H2,1-5H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.43E+3	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10071079 (2018) BindingDB Entry DOI: 10.7270/Q2VD71GV
					More data for this Ligand-Target Pair