BDBM273340 US10071079, Example 119::US10478424, Example 119

SMILES: CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cn2ncnc2c(Cl)c1C

InChI Key: InChIKey=BKDAXXJFSDTXCZ-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 273340   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 7 (Homo sapiens (Human))	BDBM273340 (US10071079, Example 119 | US10478424, Example 119) Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cn2ncnc2c(Cl)c1C Show InChI InChI=1S/C23H26ClN5/c1-13(2)20-17-10-16(15-6-8-25-9-7-15)4-5-19(17)28-22(20)18-11-29-23(26-12-27-29)21(24)14(18)3/h4-5,10-13,15,25,28H,6-9H2,1-3H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10071079 (2018) BindingDB Entry DOI: 10.7270/Q2VD71GV
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM273340 (US10071079, Example 119 | US10478424, Example 119) Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cn2ncnc2c(Cl)c1C Show InChI InChI=1S/C23H26ClN5/c1-13(2)20-17-10-16(15-6-8-25-9-7-15)4-5-19(17)28-22(20)18-11-29-23(26-12-27-29)21(24)14(18)3/h4-5,10-13,15,25,28H,6-9H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10071079 (2018) BindingDB Entry DOI: 10.7270/Q2VD71GV
					More data for this Ligand-Target Pair
Toll-like receptor 9 (Homo sapiens (Human))	BDBM273340 (US10071079, Example 119 | US10478424, Example 119) Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cn2ncnc2c(Cl)c1C Show InChI InChI=1S/C23H26ClN5/c1-13(2)20-17-10-16(15-6-8-25-9-7-15)4-5-19(17)28-22(20)18-11-29-23(26-12-27-29)21(24)14(18)3/h4-5,10-13,15,25,28H,6-9H2,1-3H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.49E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10478424 (2019) BindingDB Entry DOI: 10.7270/Q2QZ2DB0
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM273340 (US10071079, Example 119 | US10478424, Example 119) Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cn2ncnc2c(Cl)c1C Show InChI InChI=1S/C23H26ClN5/c1-13(2)20-17-10-16(15-6-8-25-9-7-15)4-5-19(17)28-22(20)18-11-29-23(26-12-27-29)21(24)14(18)3/h4-5,10-13,15,25,28H,6-9H2,1-3H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10478424 (2019) BindingDB Entry DOI: 10.7270/Q2QZ2DB0
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM273340 (US10071079, Example 119 | US10478424, Example 119) Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cn2ncnc2c(Cl)c1C Show InChI InChI=1S/C23H26ClN5/c1-13(2)20-17-10-16(15-6-8-25-9-7-15)4-5-19(17)28-22(20)18-11-29-23(26-12-27-29)21(24)14(18)3/h4-5,10-13,15,25,28H,6-9H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10478424 (2019) BindingDB Entry DOI: 10.7270/Q2QZ2DB0
					More data for this Ligand-Target Pair
Toll-like receptor 9 (Homo sapiens (Human))	BDBM273340 (US10071079, Example 119 | US10478424, Example 119) Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cn2ncnc2c(Cl)c1C Show InChI InChI=1S/C23H26ClN5/c1-13(2)20-17-10-16(15-6-8-25-9-7-15)4-5-19(17)28-22(20)18-11-29-23(26-12-27-29)21(24)14(18)3/h4-5,10-13,15,25,28H,6-9H2,1-3H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.49E+3	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10071079 (2018) BindingDB Entry DOI: 10.7270/Q2VD71GV
					More data for this Ligand-Target Pair