BDBM273647 US10071079, Example 432::US10478424, Example 432

SMILES: CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C(CCO)CCO)-c1cc(C)c2ncnn2c1

InChI Key: InChIKey=YQARXVLRQWRWNR-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 273647   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 7 (Homo sapiens (Human))	BDBM273647 (US10071079, Example 432 | US10478424, Example 432) Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C(CCO)CCO)-c1cc(C)c2ncnn2c1 Show InChI InChI=1S/C28H37N5O2/c1-18(2)26-24-15-21(20-6-10-32(11-7-20)23(8-12-34)9-13-35)4-5-25(24)31-27(26)22-14-19(3)28-29-17-30-33(28)16-22/h4-5,14-18,20,23,31,34-35H,6-13H2,1-3H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10071079 (2018) BindingDB Entry DOI: 10.7270/Q2VD71GV
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM273647 (US10071079, Example 432 | US10478424, Example 432) Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C(CCO)CCO)-c1cc(C)c2ncnn2c1 Show InChI InChI=1S/C28H37N5O2/c1-18(2)26-24-15-21(20-6-10-32(11-7-20)23(8-12-34)9-13-35)4-5-25(24)31-27(26)22-14-19(3)28-29-17-30-33(28)16-22/h4-5,14-18,20,23,31,34-35H,6-13H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10071079 (2018) BindingDB Entry DOI: 10.7270/Q2VD71GV
					More data for this Ligand-Target Pair
Toll-like receptor 9 (Homo sapiens (Human))	BDBM273647 (US10071079, Example 432 | US10478424, Example 432) Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C(CCO)CCO)-c1cc(C)c2ncnn2c1 Show InChI InChI=1S/C28H37N5O2/c1-18(2)26-24-15-21(20-6-10-32(11-7-20)23(8-12-34)9-13-35)4-5-25(24)31-27(26)22-14-19(3)28-29-17-30-33(28)16-22/h4-5,14-18,20,23,31,34-35H,6-13H2,1-3H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10478424 (2019) BindingDB Entry DOI: 10.7270/Q2QZ2DB0
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM273647 (US10071079, Example 432 | US10478424, Example 432) Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C(CCO)CCO)-c1cc(C)c2ncnn2c1 Show InChI InChI=1S/C28H37N5O2/c1-18(2)26-24-15-21(20-6-10-32(11-7-20)23(8-12-34)9-13-35)4-5-25(24)31-27(26)22-14-19(3)28-29-17-30-33(28)16-22/h4-5,14-18,20,23,31,34-35H,6-13H2,1-3H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10478424 (2019) BindingDB Entry DOI: 10.7270/Q2QZ2DB0
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM273647 (US10071079, Example 432 | US10478424, Example 432) Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C(CCO)CCO)-c1cc(C)c2ncnn2c1 Show InChI InChI=1S/C28H37N5O2/c1-18(2)26-24-15-21(20-6-10-32(11-7-20)23(8-12-34)9-13-35)4-5-25(24)31-27(26)22-14-19(3)28-29-17-30-33(28)16-22/h4-5,14-18,20,23,31,34-35H,6-13H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10478424 (2019) BindingDB Entry DOI: 10.7270/Q2QZ2DB0
					More data for this Ligand-Target Pair
Toll-like receptor 9 (Homo sapiens (Human))	BDBM273647 (US10071079, Example 432 | US10478424, Example 432) Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C(CCO)CCO)-c1cc(C)c2ncnn2c1 Show InChI InChI=1S/C28H37N5O2/c1-18(2)26-24-15-21(20-6-10-32(11-7-20)23(8-12-34)9-13-35)4-5-25(24)31-27(26)22-14-19(3)28-29-17-30-33(28)16-22/h4-5,14-18,20,23,31,34-35H,6-13H2,1-3H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.55E+3	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10071079 (2018) BindingDB Entry DOI: 10.7270/Q2VD71GV
					More data for this Ligand-Target Pair