BDBM273784 US10071079, Example 570::US10478424, Example 570

SMILES: CNCCN1CCC(CC1)c1ccc2[nH]c(c(C(C)C)c2c1)-c1cc(OC)c2ncnn2c1

InChI Key: InChIKey=UFYKYOPEBKEATB-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 273784   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 7 (Homo sapiens (Human))	BDBM273784 (US10071079, Example 570 | US10478424, Example 570) Show SMILES CNCCN1CCC(CC1)c1ccc2[nH]c(c(C(C)C)c2c1)-c1cc(OC)c2ncnn2c1 Show InChI InChI=1S/C26H34N6O/c1-17(2)24-21-13-19(18-7-10-31(11-8-18)12-9-27-3)5-6-22(21)30-25(24)20-14-23(33-4)26-28-16-29-32(26)15-20/h5-6,13-18,27,30H,7-12H2,1-4H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10071079 (2018) BindingDB Entry DOI: 10.7270/Q2VD71GV
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM273784 (US10071079, Example 570 | US10478424, Example 570) Show SMILES CNCCN1CCC(CC1)c1ccc2[nH]c(c(C(C)C)c2c1)-c1cc(OC)c2ncnn2c1 Show InChI InChI=1S/C26H34N6O/c1-17(2)24-21-13-19(18-7-10-31(11-8-18)12-9-27-3)5-6-22(21)30-25(24)20-14-23(33-4)26-28-16-29-32(26)15-20/h5-6,13-18,27,30H,7-12H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10071079 (2018) BindingDB Entry DOI: 10.7270/Q2VD71GV
					More data for this Ligand-Target Pair
Toll-like receptor 9 (Homo sapiens (Human))	BDBM273784 (US10071079, Example 570 | US10478424, Example 570) Show SMILES CNCCN1CCC(CC1)c1ccc2[nH]c(c(C(C)C)c2c1)-c1cc(OC)c2ncnn2c1 Show InChI InChI=1S/C26H34N6O/c1-17(2)24-21-13-19(18-7-10-31(11-8-18)12-9-27-3)5-6-22(21)30-25(24)20-14-23(33-4)26-28-16-29-32(26)15-20/h5-6,13-18,27,30H,7-12H2,1-4H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	535	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10478424 (2019) BindingDB Entry DOI: 10.7270/Q2QZ2DB0
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM273784 (US10071079, Example 570 | US10478424, Example 570) Show SMILES CNCCN1CCC(CC1)c1ccc2[nH]c(c(C(C)C)c2c1)-c1cc(OC)c2ncnn2c1 Show InChI InChI=1S/C26H34N6O/c1-17(2)24-21-13-19(18-7-10-31(11-8-18)12-9-27-3)5-6-22(21)30-25(24)20-14-23(33-4)26-28-16-29-32(26)15-20/h5-6,13-18,27,30H,7-12H2,1-4H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10478424 (2019) BindingDB Entry DOI: 10.7270/Q2QZ2DB0
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM273784 (US10071079, Example 570 | US10478424, Example 570) Show SMILES CNCCN1CCC(CC1)c1ccc2[nH]c(c(C(C)C)c2c1)-c1cc(OC)c2ncnn2c1 Show InChI InChI=1S/C26H34N6O/c1-17(2)24-21-13-19(18-7-10-31(11-8-18)12-9-27-3)5-6-22(21)30-25(24)20-14-23(33-4)26-28-16-29-32(26)15-20/h5-6,13-18,27,30H,7-12H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10478424 (2019) BindingDB Entry DOI: 10.7270/Q2QZ2DB0
					More data for this Ligand-Target Pair
Toll-like receptor 9 (Homo sapiens (Human))	BDBM273784 (US10071079, Example 570 | US10478424, Example 570) Show SMILES CNCCN1CCC(CC1)c1ccc2[nH]c(c(C(C)C)c2c1)-c1cc(OC)c2ncnn2c1 Show InChI InChI=1S/C26H34N6O/c1-17(2)24-21-13-19(18-7-10-31(11-8-18)12-9-27-3)5-6-22(21)30-25(24)20-14-23(33-4)26-28-16-29-32(26)15-20/h5-6,13-18,27,30H,7-12H2,1-4H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	535	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10071079 (2018) BindingDB Entry DOI: 10.7270/Q2VD71GV
					More data for this Ligand-Target Pair