BDBM27402 2-(pyridin-4-yl)-1-(2,2,2-trifluoroethyl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyridin-4-one::pyrrolopyridinone scaffold, 24

SMILES: FC(F)(F)Cn1c2CCNC(=O)c2cc1-c1ccncc1

InChI Key: InChIKey=SAKAEWAAOFPWBD-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 27402   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cdc7 Kinase (Homo sapiens (Human))	BDBM27402 (2-(pyridin-4-yl)-1-(2,2,2-trifluoroethyl)-1H,4H,5H...) Show SMILES FC(F)(F)Cn1c2CCNC(=O)c2cc1-c1ccncc1 Show InChI InChI=1S/C14H12F3N3O/c15-14(16,17)8-20-11-3-6-19-13(21)10(11)7-12(20)9-1-4-18-5-2-9/h1-2,4-5,7H,3,6,8H2,(H,19,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	7.9	25
Nerviano Medical Sciences Srl					Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...				J Med Chem 51: 487-501 (2008) Article DOI: 10.1021/jm700956r BindingDB Entry DOI: 10.7270/Q247485B
					More data for this Ligand-Target Pair