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BDBM27409 2-(2-aminopyrimidin-4-yl)-1-cyclobutyl-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyridin-4-one::pyrrolopyridinone scaffold, 31

SMILES: Nc1nccc(n1)-c1cc2c(CCNC2=O)n1C1CCC1

InChI Key: InChIKey=FZIYQGKXJVAXEJ-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 27409   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cdc7 Kinase


(Homo sapiens (Human))
BDBM27409
PNG
(2-(2-aminopyrimidin-4-yl)-1-cyclobutyl-1H,4H,5H,6H...)
Show SMILES Nc1nccc(n1)-c1cc2c(CCNC2=O)n1C1CCC1
Show InChI InChI=1S/C15H17N5O/c16-15-18-6-4-11(19-15)13-8-10-12(5-7-17-14(10)21)20(13)9-2-1-3-9/h4,6,8-9H,1-3,5,7H2,(H,17,21)(H2,16,18,19)
PDB

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KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Nerviano Medical Sciences Srl



Assay Description
The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...


J Med Chem 51: 487-501 (2008)


Article DOI: 10.1021/jm700956r
BindingDB Entry DOI: 10.7270/Q247485B
More data for this
Ligand-Target Pair