BDBM27418 2-(2-aminopyrimidin-4-yl)-1-(1-methylpiperidin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyridin-4-one::pyrrolopyridinone scaffold, 40

SMILES: CN1CCC(CC1)n1c2CCNC(=O)c2cc1-c1ccnc(N)n1

InChI Key: InChIKey=LXMODSYKNNXEKG-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 27418   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cdc7 Kinase (Homo sapiens (Human))	BDBM27418 (2-(2-aminopyrimidin-4-yl)-1-(1-methylpiperidin-4-y...) Show SMILES CN1CCC(CC1)n1c2CCNC(=O)c2cc1-c1ccnc(N)n1 Show InChI InChI=1S/C17H22N6O/c1-22-8-4-11(5-9-22)23-14-3-7-19-16(24)12(14)10-15(23)13-2-6-20-17(18)21-13/h2,6,10-11H,3-5,7-9H2,1H3,(H,19,24)(H2,18,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Nerviano Medical Sciences Srl					Assay Description The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...				J Med Chem 51: 487-501 (2008) Article DOI: 10.1021/jm700956r BindingDB Entry DOI: 10.7270/Q247485B
					More data for this Ligand-Target Pair