BDBM274222 1-(1-acetylazetidin-3-yl)-6-(4-chlorophenyl)-3-cyclopropyl-5-(3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one::US9550796, Example 17
SMILES: CC(=O)N1CC(C1)n1cc(C2CC2)c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1
InChI Key: InChIKey=CASINEGODQBEAL-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bromodomain-containing protein 4 (Homo sapiens (Human)) | BDBM274222 (1-(1-acetylazetidin-3-yl)-6-(4-chlorophenyl)-3-cyc...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <11 | n/a | n/a | n/a | n/a | 7.5 | n/a |
NOVARTIS AG US Patent | Assay Description All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... | US Patent US9550796 (2017) BindingDB Entry DOI: 10.7270/Q2QN68SK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CREB-binding protein (Homo sapiens (Human)) | BDBM274222 (1-(1-acetylazetidin-3-yl)-6-(4-chlorophenyl)-3-cyc...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
NOVARTIS AG US Patent | Assay Description All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... | US Patent US9550796 (2017) BindingDB Entry DOI: 10.7270/Q2QN68SK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 3 (Homo sapiens (Human)) | BDBM274222 (1-(1-acetylazetidin-3-yl)-6-(4-chlorophenyl)-3-cyc...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <11 | n/a | n/a | n/a | n/a | 7.5 | n/a |
NOVARTIS AG US Patent | Assay Description All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... | US Patent US9550796 (2017) BindingDB Entry DOI: 10.7270/Q2QN68SK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 2 (Homo sapiens (Human)) | BDBM274222 (1-(1-acetylazetidin-3-yl)-6-(4-chlorophenyl)-3-cyc...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <11 | n/a | n/a | n/a | n/a | 7.5 | n/a |
NOVARTIS AG US Patent | Assay Description All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... | US Patent US9550796 (2017) BindingDB Entry DOI: 10.7270/Q2QN68SK | |||||||||||
More data for this Ligand-Target Pair |