BDBM274318 6-(4-chlorophenyl)-3-cyclopropyl-2-(3,6-dihydro-2H-pyran-4-yl)-5-(3,8-di methyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1-methyl-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one::US9550796, Example 119

SMILES: Cc1nnc2c(C)cc(cn12)N1C(c2c(C1=O)c(C1CC1)c(C1=CCOCC1)n2C)c1ccc(Cl)cc1

InChI Key: InChIKey=BOMRODLYJXBVMI-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 274318   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM274318 (6-(4-chlorophenyl)-3-cyclopropyl-2-(3,6-dihydro-2H...) Show SMILES Cc1nnc2c(C)cc(cn12)N1C(c2c(C1=O)c(C1CC1)c(C1=CCOCC1)n2C)c1ccc(Cl)cc1 |t:26| Show InChI InChI=1S/C29H28ClN5O2/c1-16-14-22(15-34-17(2)31-32-28(16)34)35-26(19-6-8-21(30)9-7-19)27-24(29(35)36)23(18-4-5-18)25(33(27)3)20-10-12-37-13-11-20/h6-10,14-15,18,26H,4-5,11-13H2,1-3H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<11	n/a	n/a	n/a	n/a	7.5	n/a
NOVARTIS AG US Patent					Assay Description All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...				US Patent US9550796 (2017) BindingDB Entry DOI: 10.7270/Q2QN68SK
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM274318 (6-(4-chlorophenyl)-3-cyclopropyl-2-(3,6-dihydro-2H...) Show SMILES Cc1nnc2c(C)cc(cn12)N1C(c2c(C1=O)c(C1CC1)c(C1=CCOCC1)n2C)c1ccc(Cl)cc1 |t:26| Show InChI InChI=1S/C29H28ClN5O2/c1-16-14-22(15-34-17(2)31-32-28(16)34)35-26(19-6-8-21(30)9-7-19)27-24(29(35)36)23(18-4-5-18)25(33(27)3)20-10-12-37-13-11-20/h6-10,14-15,18,26H,4-5,11-13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	7.5	30
NOVARTIS AG US Patent					Assay Description All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...				US Patent US9550796 (2017) BindingDB Entry DOI: 10.7270/Q2QN68SK
					More data for this Ligand-Target Pair
Bromodomain-containing protein 3 (Homo sapiens (Human))	BDBM274318 (6-(4-chlorophenyl)-3-cyclopropyl-2-(3,6-dihydro-2H...) Show SMILES Cc1nnc2c(C)cc(cn12)N1C(c2c(C1=O)c(C1CC1)c(C1=CCOCC1)n2C)c1ccc(Cl)cc1 |t:26| Show InChI InChI=1S/C29H28ClN5O2/c1-16-14-22(15-34-17(2)31-32-28(16)34)35-26(19-6-8-21(30)9-7-19)27-24(29(35)36)23(18-4-5-18)25(33(27)3)20-10-12-37-13-11-20/h6-10,14-15,18,26H,4-5,11-13H2,1-3H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<11	n/a	n/a	n/a	n/a	7.5	n/a
NOVARTIS AG US Patent					Assay Description All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...				US Patent US9550796 (2017) BindingDB Entry DOI: 10.7270/Q2QN68SK
					More data for this Ligand-Target Pair