BDBM274452 N-(6-(1-(1-((1H-pyrazol-5- yl)methyl)piperidin-4-yl)-4-(4- fluorophenyl)-1H-imidazol-5- yl)imidazo[1,2-b]pyridazin-2-yl)-2- fluoroisonicotinamide::US9556179, Compound 21

SMILES: Cc1nn(C)cc1CN1CCC(CC1)n1cnc(c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1

InChI Key: InChIKey=KNPVWXBCYSNVIK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274452   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Casein kinase I isoform delta (Homo sapiens (Human))	BDBM274452 (N-(6-(1-(1-((1H-pyrazol-5- yl)methyl)piperidin-4-y...) Show SMILES Cc1nn(C)cc1CN1CCC(CC1)n1cnc(c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C32H30F2N10O/c1-20-23(16-41(2)39-20)17-42-13-10-25(11-14-42)43-19-36-30(21-3-5-24(33)6-4-21)31(43)26-7-8-29-37-28(18-44(29)40-26)38-32(45)22-9-12-35-27(34)15-22/h3-9,12,15-16,18-19,25H,10-11,13-14,17H2,1-2H3,(H,38,45)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair
Casein kinase I isoform epsilon (Homo sapiens (Human))	BDBM274452 (N-(6-(1-(1-((1H-pyrazol-5- yl)methyl)piperidin-4-y...) Show SMILES Cc1nn(C)cc1CN1CCC(CC1)n1cnc(c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C32H30F2N10O/c1-20-23(16-41(2)39-20)17-42-13-10-25(11-14-42)43-19-36-30(21-3-5-24(33)6-4-21)31(43)26-7-8-29-37-28(18-44(29)40-26)38-32(45)22-9-12-35-27(34)15-22/h3-9,12,15-16,18-19,25H,10-11,13-14,17H2,1-2H3,(H,38,45)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.56	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair