BDBM274477 N-(6-(1-(1-(2-cyanoacetyl)piperidin-4- yl)-4-(4-fluorophenyl)-1H-imidazol-5- yl)imidazo[1,2-b]pyridazin-2-yl)-2- fluoroisonicotinamide::US9556179, Compound 46

SMILES: Fc1ccc(cc1)-c1ncn(C2CCN(CC2)C(=O)C[N+]#[C-])c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1

InChI Key: InChIKey=VLVRECTTXHRPCC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274477   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Casein kinase I isoform delta (Homo sapiens (Human))	BDBM274477 (N-(6-(1-(1-(2-cyanoacetyl)piperidin-4- yl)-4-(4-fl...) Show SMILES Fc1ccc(cc1)-c1ncn(C2CCN(CC2)C(=O)C[N+]#[C-])c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1 Show InChI InChI=1S/C29H23F2N9O2/c1-32-15-26(41)38-12-9-21(10-13-38)39-17-34-27(18-2-4-20(30)5-3-18)28(39)22-6-7-25-35-24(16-40(25)37-22)36-29(42)19-8-11-33-23(31)14-19/h2-8,11,14,16-17,21H,9-10,12-13,15H2,(H,36,42)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.198	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair
Casein kinase I isoform epsilon (Homo sapiens (Human))	BDBM274477 (N-(6-(1-(1-(2-cyanoacetyl)piperidin-4- yl)-4-(4-fl...) Show SMILES Fc1ccc(cc1)-c1ncn(C2CCN(CC2)C(=O)C[N+]#[C-])c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1 Show InChI InChI=1S/C29H23F2N9O2/c1-32-15-26(41)38-12-9-21(10-13-38)39-17-34-27(18-2-4-20(30)5-3-18)28(39)22-6-7-25-35-24(16-40(25)37-22)36-29(42)19-8-11-33-23(31)14-19/h2-8,11,14,16-17,21H,9-10,12-13,15H2,(H,36,42)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.743	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair