BDBM274492 2-fluoro-N-(6-(4-(4-fluorophenyl)-1-(1- (2-morpholinoacetyl)piperidin-4-yl)-1H- imidazol-5-yl)imidazo[1,2-b]pyridazin- 2-yl)isonicotinamide::US9556179, Compound 61

SMILES: Fc1ccc(cc1)-c1ncn(C2CCN(CC2)C(=O)CN2CCOCC2)c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1

InChI Key: InChIKey=MBCOGDHKKUVOIO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274492   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Casein kinase I isoform delta (Homo sapiens (Human))	BDBM274492 (2-fluoro-N-(6-(4-(4-fluorophenyl)-1-(1- (2-morphol...) Show SMILES Fc1ccc(cc1)-c1ncn(C2CCN(CC2)C(=O)CN2CCOCC2)c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1 Show InChI InChI=1S/C32H31F2N9O3/c33-23-3-1-21(2-4-23)30-31(42(20-36-30)24-8-11-41(12-9-24)29(44)19-40-13-15-46-16-14-40)25-5-6-28-37-27(18-43(28)39-25)38-32(45)22-7-10-35-26(34)17-22/h1-7,10,17-18,20,24H,8-9,11-16,19H2,(H,38,45)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.186	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair
Casein kinase I isoform epsilon (Homo sapiens (Human))	BDBM274492 (2-fluoro-N-(6-(4-(4-fluorophenyl)-1-(1- (2-morphol...) Show SMILES Fc1ccc(cc1)-c1ncn(C2CCN(CC2)C(=O)CN2CCOCC2)c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1 Show InChI InChI=1S/C32H31F2N9O3/c33-23-3-1-21(2-4-23)30-31(42(20-36-30)24-8-11-41(12-9-24)29(44)19-40-13-15-46-16-14-40)25-5-6-28-37-27(18-43(28)39-25)38-32(45)22-7-10-35-26(34)17-22/h1-7,10,17-18,20,24H,8-9,11-16,19H2,(H,38,45)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.26	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair