BDBM274499 N-(6-(1-(1- (cyclobutanecarbonyl)piperidin-4-yl)-4- (4-fluorophenyl)-1H-imidazol-5- yl)imidazo[1,2-b]pyridazin-2-yl)-2- fluoroisonicotinamide::US9556179, Compound 68

SMILES: Fc1ccc(cc1)-c1ncn(C2CCN(CC2)C(=O)C2CCC2)c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1

InChI Key: InChIKey=CTKLFQNNPDELPW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274499   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Casein kinase I isoform delta (Homo sapiens (Human))	BDBM274499 (N-(6-(1-(1- (cyclobutanecarbonyl)piperidin-4-yl)-4...) Show SMILES Fc1ccc(cc1)-c1ncn(C2CCN(CC2)C(=O)C2CCC2)c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1 Show InChI InChI=1S/C31H28F2N8O2/c32-22-6-4-19(5-7-22)28-29(40(18-35-28)23-11-14-39(15-12-23)31(43)20-2-1-3-20)24-8-9-27-36-26(17-41(27)38-24)37-30(42)21-10-13-34-25(33)16-21/h4-10,13,16-18,20,23H,1-3,11-12,14-15H2,(H,37,42)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.193	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair
Casein kinase I isoform epsilon (Homo sapiens (Human))	BDBM274499 (N-(6-(1-(1- (cyclobutanecarbonyl)piperidin-4-yl)-4...) Show SMILES Fc1ccc(cc1)-c1ncn(C2CCN(CC2)C(=O)C2CCC2)c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1 Show InChI InChI=1S/C31H28F2N8O2/c32-22-6-4-19(5-7-22)28-29(40(18-35-28)23-11-14-39(15-12-23)31(43)20-2-1-3-20)24-8-9-27-36-26(17-41(27)38-24)37-30(42)21-10-13-34-25(33)16-21/h4-10,13,16-18,20,23H,1-3,11-12,14-15H2,(H,37,42)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.811	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair