BDBM274510 US9556179, Compound 80::oxetan-3-yl 4-(5-(2-(2- fluoroisonicotinamido)imidazo[1,2- b]pyridazin-6-yl)-4-(4-fluorophenyl)- 1H-imidazol-1-yl)piperidine-1- carboxylate
SMILES: Fc1ccc(cc1)-c1ncn(C2CCN(CC2)C(=O)OC2COC2)c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1
InChI Key: InChIKey=YJNVHDXGHUWUIS-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Casein kinase I isoform delta (Homo sapiens (Human)) | BDBM274510 (US9556179, Compound 80 | oxetan-3-yl 4-(5-(2-(2- f...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.171 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Bristol-Myers Squibb Company US Patent | Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst... | US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Casein kinase I isoform epsilon (Homo sapiens (Human)) | BDBM274510 (US9556179, Compound 80 | oxetan-3-yl 4-(5-(2-(2- f...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.809 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Bristol-Myers Squibb Company US Patent | Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst... | US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5 | |||||||||||
More data for this Ligand-Target Pair |