BDBM274527 N-(6-(4-(4-fluorophenyl)-1- (1-(2-hydroxyethyl)piperidin- 4-yl)-1H-imidazol-5-yl)imidazo [1,2-b]pyridazin-2-yl)- 4-methyl-2-(pyridin-3-yl) thiazole-5-carboxamide::US9556179, Compound 97

SMILES: Cc1nc(sc1C(=O)Nc1cn2nc(ccc2n1)-c1c(ncn1C1CCN(CCO)CC1)-c1ccc(F)cc1)-c1cccnc1

InChI Key: InChIKey=VWRHQHAMAYVOOK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274527   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Casein kinase I isoform delta (Homo sapiens (Human))	BDBM274527 (N-(6-(4-(4-fluorophenyl)-1- (1-(2-hydroxyethyl)pip...) Show SMILES Cc1nc(sc1C(=O)Nc1cn2nc(ccc2n1)-c1c(ncn1C1CCN(CCO)CC1)-c1ccc(F)cc1)-c1cccnc1 Show InChI InChI=1S/C32H30FN9O2S/c1-20-30(45-32(36-20)22-3-2-12-34-17-22)31(44)38-26-18-42-27(37-26)9-8-25(39-42)29-28(21-4-6-23(33)7-5-21)35-19-41(29)24-10-13-40(14-11-24)15-16-43/h2-9,12,17-19,24,43H,10-11,13-16H2,1H3,(H,38,44)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0340	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair
Casein kinase I isoform epsilon (Homo sapiens (Human))	BDBM274527 (N-(6-(4-(4-fluorophenyl)-1- (1-(2-hydroxyethyl)pip...) Show SMILES Cc1nc(sc1C(=O)Nc1cn2nc(ccc2n1)-c1c(ncn1C1CCN(CCO)CC1)-c1ccc(F)cc1)-c1cccnc1 Show InChI InChI=1S/C32H30FN9O2S/c1-20-30(45-32(36-20)22-3-2-12-34-17-22)31(44)38-26-18-42-27(37-26)9-8-25(39-42)29-28(21-4-6-23(33)7-5-21)35-19-41(29)24-10-13-40(14-11-24)15-16-43/h2-9,12,17-19,24,43H,10-11,13-16H2,1H3,(H,38,44)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0950	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair