BDBM274578 2-fluoro-N-(6-(4-(4- fluorophenyl)-1-(1- (2-hydroxyethyl)azetidin- 3-yl)-1H-imidazol-5- yl)imidazo[1,2-b]pyridazin- 2-yl)isonicotinamide::US9556179, Compound 150

SMILES: OCCN1CC(C1)n1cnc(c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1

InChI Key: InChIKey=HPZZSDXVAGJJPP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274578   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Casein kinase I isoform delta (Homo sapiens (Human))	BDBM274578 (2-fluoro-N-(6-(4-(4- fluorophenyl)-1-(1- (2-hydrox...) Show SMILES OCCN1CC(C1)n1cnc(c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C26H22F2N8O2/c27-18-3-1-16(2-4-18)24-25(35(15-30-24)19-12-34(13-19)9-10-37)20-5-6-23-31-22(14-36(23)33-20)32-26(38)17-7-8-29-21(28)11-17/h1-8,11,14-15,19,37H,9-10,12-13H2,(H,32,38)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0340	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair
Casein kinase I isoform epsilon (Homo sapiens (Human))	BDBM274578 (2-fluoro-N-(6-(4-(4- fluorophenyl)-1-(1- (2-hydrox...) Show SMILES OCCN1CC(C1)n1cnc(c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C26H22F2N8O2/c27-18-3-1-16(2-4-18)24-25(35(15-30-24)19-12-34(13-19)9-10-37)20-5-6-23-31-22(14-36(23)33-20)32-26(38)17-7-8-29-21(28)11-17/h1-8,11,14-15,19,37H,9-10,12-13H2,(H,32,38)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.81	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair