BDBM274593 N-(6-(4-(4-fluorophenyl)-1- (2-morpholinoethyl)-1H- imidazol-5-yl)imidazo[1,2-b] pyridazin-2-yl)quinoline- 4-carboxamide::US9556179, Compound 166

SMILES: Fc1ccc(cc1)-c1ncn(C2CCN(CCN3CCOCC3)CC2)c1-c1ccc2nc(NC(=O)c3ccnc4ccccc34)cn2n1

InChI Key: InChIKey=SACXILLSXPBWDP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274593   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Casein kinase I isoform delta (Homo sapiens (Human))	BDBM274593 (N-(6-(4-(4-fluorophenyl)-1- (2-morpholinoethyl)-1H...) Show SMILES Fc1ccc(cc1)-c1ncn(C2CCN(CCN3CCOCC3)CC2)c1-c1ccc2nc(NC(=O)c3ccnc4ccccc34)cn2n1 Show InChI InChI=1S/C36H36FN9O2/c37-26-7-5-25(6-8-26)34-35(45(24-39-34)27-12-15-43(16-13-27)17-18-44-19-21-48-22-20-44)31-9-10-33-40-32(23-46(33)42-31)41-36(47)29-11-14-38-30-4-2-1-3-28(29)30/h1-11,14,23-24,27H,12-13,15-22H2,(H,41,47)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.192	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair
Casein kinase I isoform epsilon (Homo sapiens (Human))	BDBM274593 (N-(6-(4-(4-fluorophenyl)-1- (2-morpholinoethyl)-1H...) Show SMILES Fc1ccc(cc1)-c1ncn(C2CCN(CCN3CCOCC3)CC2)c1-c1ccc2nc(NC(=O)c3ccnc4ccccc34)cn2n1 Show InChI InChI=1S/C36H36FN9O2/c37-26-7-5-25(6-8-26)34-35(45(24-39-34)27-12-15-43(16-13-27)17-18-44-19-21-48-22-20-44)31-9-10-33-40-32(23-46(33)42-31)41-36(47)29-11-14-38-30-4-2-1-3-28(29)30/h1-11,14,23-24,27H,12-13,15-22H2,(H,41,47)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair