BDBM274594 N-(6-(4-(4-fluorophenyl)-1- (2-morpholinoethyl)-1H- imidazol-5-yl)imidazo[1,2-b] pyridazin-2-yl)-3- (pyridin-3-yl)benzamide::US9556179, Compound 167

SMILES: Fc1ccc(cc1)-c1ncn(C2CCN(CCN3CCOCC3)CC2)c1-c1ccc2nc(NC(=O)c3cccc(c3)-c3cccnc3)cn2n1

InChI Key: InChIKey=YVIHZBQQIGEDLF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274594   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Casein kinase I isoform delta (Homo sapiens (Human))	BDBM274594 (N-(6-(4-(4-fluorophenyl)-1- (2-morpholinoethyl)-1H...) Show SMILES Fc1ccc(cc1)-c1ncn(C2CCN(CCN3CCOCC3)CC2)c1-c1ccc2nc(NC(=O)c3cccc(c3)-c3cccnc3)cn2n1 Show InChI InChI=1S/C38H38FN9O2/c39-31-8-6-27(7-9-31)36-37(47(26-41-36)32-12-15-45(16-13-32)17-18-46-19-21-50-22-20-46)33-10-11-35-42-34(25-48(35)44-33)43-38(49)29-4-1-3-28(23-29)30-5-2-14-40-24-30/h1-11,14,23-26,32H,12-13,15-22H2,(H,43,49)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.104	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair
Casein kinase I isoform epsilon (Homo sapiens (Human))	BDBM274594 (N-(6-(4-(4-fluorophenyl)-1- (2-morpholinoethyl)-1H...) Show SMILES Fc1ccc(cc1)-c1ncn(C2CCN(CCN3CCOCC3)CC2)c1-c1ccc2nc(NC(=O)c3cccc(c3)-c3cccnc3)cn2n1 Show InChI InChI=1S/C38H38FN9O2/c39-31-8-6-27(7-9-31)36-37(47(26-41-36)32-12-15-45(16-13-32)17-18-46-19-21-50-22-20-46)33-10-11-35-42-34(25-48(35)44-33)43-38(49)29-4-1-3-28(23-29)30-5-2-14-40-24-30/h1-11,14,23-26,32H,12-13,15-22H2,(H,43,49)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.687	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair