BDBM274619 2-(dimethylamino)-N-(6-(2-(4- fluorophenyl)imidazo[1,2-a] pyridin-3-yl)imidazo[1,2-b] pyridazin-2-yl) isonicotinamide::US9556179, Compound 193

SMILES: CN(C)c1cc(ccn1)C(=O)Nc1cn2nc(ccc2n1)-c1c(nc2ccccn12)-c1ccc(F)cc1

InChI Key: InChIKey=FQVXAJNTDNBERQ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274619   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Casein kinase I isoform delta (Homo sapiens (Human))	BDBM274619 (2-(dimethylamino)-N-(6-(2-(4- fluorophenyl)imidazo...) Show SMILES CN(C)c1cc(ccn1)C(=O)Nc1cn2nc(ccc2n1)-c1c(nc2ccccn12)-c1ccc(F)cc1 Show InChI InChI=1S/C27H21FN8O/c1-34(2)24-15-18(12-13-29-24)27(37)31-21-16-36-23(30-21)11-10-20(33-36)26-25(17-6-8-19(28)9-7-17)32-22-5-3-4-14-35(22)26/h3-16H,1-2H3,(H,31,37)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.111	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair
Casein kinase I isoform epsilon (Homo sapiens (Human))	BDBM274619 (2-(dimethylamino)-N-(6-(2-(4- fluorophenyl)imidazo...) Show SMILES CN(C)c1cc(ccn1)C(=O)Nc1cn2nc(ccc2n1)-c1c(nc2ccccn12)-c1ccc(F)cc1 Show InChI InChI=1S/C27H21FN8O/c1-34(2)24-15-18(12-13-29-24)27(37)31-21-16-36-23(30-21)11-10-20(33-36)26-25(17-6-8-19(28)9-7-17)32-22-5-3-4-14-35(22)26/h3-16H,1-2H3,(H,31,37)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.28	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair