BDBM274690 2-fluoro-N-(6-(4-(4-fluorophenyl)- 1-(2-(1H-pyrazol-4-yl)ethyl-1H- imidazol-5-yl)imidazo[1,2-b] pyridazin-2-yl)isonicotinamide::US9556179, Compound 265

SMILES: Fc1ccc(cc1)-c1ncn(CCc2cn[nH]c2)c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1

InChI Key: InChIKey=GYNUZCYLUKTVHK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274690   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Casein kinase I isoform delta (Homo sapiens (Human))	BDBM274690 (2-fluoro-N-(6-(4-(4-fluorophenyl)- 1-(2-(1H-pyrazo...) Show SMILES Fc1ccc(cc1)-c1ncn(CCc2cn[nH]c2)c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1 Show InChI InChI=1S/C26H19F2N9O/c27-19-3-1-17(2-4-19)24-25(36(15-30-24)10-8-16-12-31-32-13-16)20-5-6-23-33-22(14-37(23)35-20)34-26(38)18-7-9-29-21(28)11-18/h1-7,9,11-15H,8,10H2,(H,31,32)(H,34,38)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.147	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair
Casein kinase I isoform epsilon (Homo sapiens (Human))	BDBM274690 (2-fluoro-N-(6-(4-(4-fluorophenyl)- 1-(2-(1H-pyrazo...) Show SMILES Fc1ccc(cc1)-c1ncn(CCc2cn[nH]c2)c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1 Show InChI InChI=1S/C26H19F2N9O/c27-19-3-1-17(2-4-19)24-25(36(15-30-24)10-8-16-12-31-32-13-16)20-5-6-23-33-22(14-37(23)35-20)34-26(38)18-7-9-29-21(28)11-18/h1-7,9,11-15H,8,10H2,(H,31,32)(H,34,38)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.719	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair