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BDBM2747 Alkenyldiarylmethane (ADAM) 15::Alkenyldiarylmethanes (ADAM) 15::Methyl 3,3-Dichloro-4,4-dimethoxy-5,5-bis(methoxycarbonyl)-3,3-diphenylpropenoate::methyl 3-chloro-5-{1-[3-chloro-4-methoxy-5-(methoxycarbonyl)phenyl]-3-methoxy-3-oxoprop-1-en-1-yl}-2-methoxybenzoate

SMILES: [#6]-[#8]-[#6](=O)\[#6]=[#6](\c1cc(Cl)c(-[#8]-[#6])c(c1)-[#6](=O)-[#8]-[#6])-c1cc(Cl)c(-[#8]-[#6])c(c1)-[#6](=O)-[#8]-[#6]

InChI Key: InChIKey=HVCSWQRDGTUVLM-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 2747   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)		BDBM2747
PNG
(Alkenyldiarylmethane (ADAM) 15 | Alkenyldiarylmeth...)
Show SMILES [#6]-[#8]-[#6](=O)\[#6]=[#6](\c1cc(Cl)c(-[#8]-[#6])c(c1)-[#6](=O)-[#8]-[#6])-c1cc(Cl)c(-[#8]-[#6])c(c1)-[#6](=O)-[#8]-[#6]
Show InChI InChI=1S/C22H20Cl2O8/c1-28-18(25)10-13(11-6-14(21(26)31-4)19(29-2)16(23)8-11)12-7-15(22(27)32-5)20(30-3)17(24)9-12/h6-10H,1-5H3
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PC sid
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Similars
Article
PubMed
n/an/a 1.60E+4n/an/an/an/a7.9n/a



Purdue University



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 41: 2076-89 (1998)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q2251GC2
More data for this
Ligand-Target Pair