BDBM274763 N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol-5-yl) imidazo[1,2-b]pyridazin-2- yl)isoquinoline-6- carboxamide::US9556179, Compound 339

SMILES: Cc1nc(c(-c2ccc3nc(NC(=O)c4ccc5cnccc5c4)cn3n2)n1C)-c1ccc(F)cc1

InChI Key: InChIKey=ZMKKMWNCVZGKTI-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274763   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Casein kinase I isoform delta (Homo sapiens (Human))	BDBM274763 (N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...) Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4ccc5cnccc5c4)cn3n2)n1C)-c1ccc(F)cc1 Show InChI InChI=1S/C27H20FN7O/c1-16-30-25(17-5-7-21(28)8-6-17)26(34(16)2)22-9-10-24-31-23(15-35(24)33-22)32-27(36)19-3-4-20-14-29-12-11-18(20)13-19/h3-15H,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.187	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair
Casein kinase I isoform epsilon (Homo sapiens (Human))	BDBM274763 (N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...) Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4ccc5cnccc5c4)cn3n2)n1C)-c1ccc(F)cc1 Show InChI InChI=1S/C27H20FN7O/c1-16-30-25(17-5-7-21(28)8-6-17)26(34(16)2)22-9-10-24-31-23(15-35(24)33-22)32-27(36)19-3-4-20-14-29-12-11-18(20)13-19/h3-15H,1-2H3,(H,32,36)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.61	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair