BDBM27497 2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide::2-Dimethylamino-N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)-acetamide::CHEMBL372303::N-(6-oxo-5,6-dihydro- phenanthridin-2-yl)-N,N-dimethylacetamide::N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE::PJ34
SMILES: CN(C)CC(=O)Nc1ccc2[nH]c(=O)c3ccccc3c2c1
InChI Key: InChIKey=UYJZZVDLGDDTCL-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | 7.8 | 22 |
University of Konstanz | Assay Description The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P... | Mol Pharmacol 74: 1587-98 (2008) Article DOI: 10.1124/mol.108.048751 BindingDB Entry DOI: 10.7270/Q2M61HKG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Naples Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal GST-tagged TNKS2 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated... | ACS Med Chem Lett 11: 862-868 (2020) | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | 8.0 | 23 |
Deltagen Research Laboratories | Assay Description To assess the inhibitory activity of novel inhibitors, the PARP-1 enzyme assay was carried out in reaction mixture consisting of Escherichia coli str... | Bioorg Med Chem Lett 18: 5126-9 (2008) Article DOI: 10.1016/j.bmcl.2008.07.091 BindingDB Entry DOI: 10.7270/Q29S1PCX | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Fujisawa Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description In vitro inhibitory concentration against Poly(ADP-ribose) polymerase 1 | Bioorg Med Chem Lett 15: 4221-5 (2005) Article DOI: 10.1016/j.bmcl.2005.06.094 BindingDB Entry DOI: 10.7270/Q2VH5NDP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Huazhong University of Science and Technology Curated by ChEMBL | Assay Description Inhibition of human recombinant PARP1 | J Med Chem 52: 718-25 (2009) Article DOI: 10.1021/jm800902t BindingDB Entry DOI: 10.7270/Q2C53KPW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD3 or PARP3) (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a |
Institutet Curated by ChEMBL | Assay Description Binding affinity to human PARP3 PARP domain by isothermal titration colorimetry | J Med Chem 52: 3108-11 (2009) Article DOI: 10.1021/jm900052j BindingDB Entry DOI: 10.7270/Q2B56JNV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a |
Institutet Curated by ChEMBL | Assay Description Binding affinity to human PARP1 by isothermal titration colorimetry | J Med Chem 52: 3108-11 (2009) Article DOI: 10.1021/jm900052j BindingDB Entry DOI: 10.7270/Q2B56JNV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Institutet Curated by ChEMBL | Assay Description Inhibition of human PARP1 | J Med Chem 52: 3108-11 (2009) Article DOI: 10.1021/jm900052j BindingDB Entry DOI: 10.7270/Q2B56JNV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Johns Hopkins University Brain Science Institute Curated by ChEMBL | Assay Description Inhibition of PARP1 | J Med Chem 53: 4561-84 (2010) Article DOI: 10.1021/jm100012m BindingDB Entry DOI: 10.7270/Q2NV9JF0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
St. John's University Curated by ChEMBL | Assay Description Inhibition of PARP1 using TACS-Sapphire substrate for 30 mins by colorimetry | Eur J Med Chem 50: 264-73 (2012) Article DOI: 10.1016/j.ejmech.2012.02.001 BindingDB Entry DOI: 10.7270/Q2FT8MGP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
University of Oulu Curated by ChEMBL | Assay Description Inhibition of ARTD1 (unknown origin) | ACS Med Chem Lett 5: 18-22 (2014) Article DOI: 10.1021/ml400292s BindingDB Entry DOI: 10.7270/Q2SB477R | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University in Saint Louis Curated by ChEMBL | Assay Description Inhibition of PARP-1 (unknown origin) assessed as NAD+ consumption after 20 mins by fluorometric analysis in presence of activated DNA | Bioorg Med Chem 22: 1700-7 (2014) Article DOI: 10.1016/j.bmc.2014.01.019 BindingDB Entry DOI: 10.7270/Q2TX3GVH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 1.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of recombinant human TNKS1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Protein mono-ADP-ribosyltransferase PARP3 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 1.43E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 14 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 4.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of recombinant human His6-tagged PARP14 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 479 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of recombinant human His6-tagged PARP1 C-3-zinc finger domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of full length recombinant human His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Protein mono-ADP-ribosyltransferase PARP3 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 1.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 382 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of recombinant human His6-tagged PARP2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of recombinant human His6-tagged PARP2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 4 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 759 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of recombinant human His6-tagged PARP4 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of recombinant human His6-tagged PARP1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 481 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of recombinant human His6-tagged PARP1 C-3-zinc finger domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of recombinant human His6-tagged PARP1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of recombinant human TNKS1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 15 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 8.91E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of recombinant human His6-tagged PARP15 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 12 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 224 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of recombinant human His6-tagged PARP12 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 2.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 10 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of full length recombinant human His6-tagged PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 12 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of recombinant human His6-tagged PARP12 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 14 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of recombinant human His6-tagged PARP14 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 10 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 5.89E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of full length recombinant human His6-tagged PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 15 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of recombinant human His6-tagged PARP15 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 10 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 6.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of recombinant human His6-tagged PARP10 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 10 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 6.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Health& Science University Curated by ChEMBL | Assay Description Inhibition of recombinant human His6-tagged PARP10 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol... | J Med Chem 60: 1262-1271 (2017) BindingDB Entry DOI: 10.7270/Q28054VV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 2 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's Center for Biomedical REsearch Curated by ChEMBL | Assay Description Concentration required to achieve 50% inhibition against 4-hydroxyphenylpyruvate dioxygenase from pig liver; (observed value) | J Nat Prod 80: 2741-2750 (2017) Article DOI: 10.1021/acs.jnatprod.7b00515 BindingDB Entry DOI: 10.7270/Q2GH9MHQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Naples Curated by ChEMBL | Assay Description Inhibition of full length human C-terminal His-tagged PARP1 expressed in baculovirus infected Sf9 cells using chicken core histone as substrate incub... | ACS Med Chem Lett 11: 862-868 (2020) | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Naples Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal His-tagged PARP2 expressed in baculovirus infected Sf9 cells using histone H3.3 as substrate incubated for... | ACS Med Chem Lett 11: 862-868 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Naples Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal GST-tagged TNKS1 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated... | ACS Med Chem Lett 11: 862-868 (2020) | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
poly-ADP-ribose polymerase 2 (PARP2) (Mus musculus (Mouse)) | BDBM27497 (2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 62 | n/a | n/a | n/a | n/a | 7.8 | 22 |
University of Konstanz | Assay Description The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P... | Mol Pharmacol 74: 1587-98 (2008) Article DOI: 10.1124/mol.108.048751 BindingDB Entry DOI: 10.7270/Q2M61HKG | |||||||||||
More data for this Ligand-Target Pair |